Sodium citrate structure
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Common Name | Sodium citrate | ||
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CAS Number | 68-04-2 | Molecular Weight | 258.069 | |
Density | 1.008 g/mL at 20 °C | Boiling Point | N/A | |
Molecular Formula | C6H5Na3O7 | Melting Point | 300°C | |
MSDS | Chinese USA | Flash Point | N/A |
Use of Sodium citrateCitric acid trisodium is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium causes renal toxicity in mice[1][2][3]. |
Name | Sodium citrate |
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Synonym | More Synonyms |
Description | Citric acid trisodium is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium causes renal toxicity in mice[1][2][3]. |
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Related Catalog | |
In Vitro | Citric acid trisodium (0-12.5 mM; 24 h) shows antiproliferative activity in a dose dependent manner[3]. Citric acid trisodium (12.5 mM; 72 h) induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner[3]. Citric acid trisodium (12.5 mM; 48 h) increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl[3]. Cell Viability Assay[3] Cell Line: HaCaT cells Concentration: 0, 2.5, 5, 7.5, 10, 12.5 mM Incubation Time: 24 h Result: Inhibited the cell viability in a dose dependent manner. Cell Cycle Analysis[3] Cell Line: HaCaT cells Concentration: 12.5 mM Incubation Time: 0, 12, 24, 48, 72 h Result: Induced apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner. Western Blot Analysis[3] Cell Line: HaCaT cells Concentration: 12.5 mM Incubation Time: 12, 24, 48 h Result: Increased the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreased of BCL-2 and BCL-Xl. |
In Vivo | Citric acid trisodium (120, 240, and 480 mg/kg; i.p.) significantly decreases GSH-Px activity and induces an increase in the MDA (malonyldialdehyde) levels in mouse liver[1]. Citric acid trisodium (120, 240, and 480 mg/kg; i.p.) induces apoptosis by increases caspase-3 activity in a dose-dependent manner in mouse hepatocytes[1]. Citric acid trisodium (120, 240, and 480 mg/kg; i.p.; weekly for 3 weeks) causes renal toxicity in mice[2]. Animal Model: 20 g male Kunming mice[2] Dosage: 120, 240, 480 mg/kg Administration: I.p.; weekly for 3 weeks Result: T-SOD and GSH-Px activities in the treated groups decreased with increasing doses of citric acid, NOS activity tended to increase, and H2O2 and MDA contents gradually decreased. |
References |
Density | 1.008 g/mL at 20 °C |
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Melting Point | 300°C |
Molecular Formula | C6H5Na3O7 |
Molecular Weight | 258.069 |
Exact Mass | 257.972839 |
PSA | 140.62000 |
Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Hazard Codes | Xi,C |
Risk Phrases | R22:Harmful if swallowed. R40:Limited evidence of a carcinogenic effect. R48/20/22:Harmful: danger of serious damage to health by prolonged exposure through inhalation and if swallowed . |
Safety Phrases | S36-S24/25 |
RIDADR | NONH for all modes of transport |
WGK Germany | 2 |
RTECS | GE8300000 |
HS Code | 2918150000 |
~% Sodium citrate CAS#:68-04-2 |
Literature: Preiss-Bloom, Orahn; Attar, Ishay; Iram, Natalie; Komlos, Chagai; Haber, Meir Patent: US2011/110882 A1, 2011 ; |
~82% Sodium citrate CAS#:68-04-2 |
Literature: Romeo, G.; Lisi, F. Riv. Ital. Essenze-Profumi Piante Offic. Olii Vegetali-Saponi, 1935 , vol. 17, p. 310 - 312 Full Text Show Details Gmelin Handbook: Na: SVol.4, 39, page 1453 - 1455 |
~% Sodium citrate CAS#:68-04-2 |
Literature: Berthelot, M.; Louguinine, V. Ann. Chim. Phys., 1976 , vol. 9, p. 13 - 23 Full Text Show Details Massol, G. Ann. Chim. Phys., 1894 , vol. 1, p. 145 - 227 Full Text Show Details Gmelin Handbook: Na: SVol.4, 39, page 1453 - 1455 Full Text Show Details Thomsen, J. Thermochemische Untersuchungen, Stuttgart 1906, S. 58 |
Precursor 3 | |
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DownStream 9 | |
HS Code | 2918150000 |
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Summary | 2918150000. other salts and esters of citric acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:4ABXY(export license,certificate of inspection for goods inward,certificate of inspection for goods outwardexport license(processing trade),export license(border small volume trade)). MFN tariff:6.5%. General tariff:30.0% |
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FEMA 3026 |
trisodium citrate |
anhydrous sodium citrate |
Na3-citrate |
citnatin |
citrosodna |
citrosodina |
MFCD00012462 |
natrocitral |
citric acid trisodium salt |
citreme |
citrosodine |
anhydrous trisodium citrate |
Citric acid 3Na |
EINECS 200-675-3 |