H-Trp-Phe-OH

Modify Date: 2024-01-07 16:21:17

H-Trp-Phe-OH Structure
H-Trp-Phe-OH structure
 Common Name H-Trp-Phe-OH
CAS Number 6686-02-8 Molecular Weight 351.39900
Density 1.319g/cm3 Boiling Point 688.3ºC at 760 mmHg
Molecular Formula C20H21N3O3 Melting Point N/A
MSDS N/A Flash Point 370.1ºC

 Use of H-Trp-Phe-OH


H-Trp-Phe-OH is a dipeptide consisting of tryptophan and phenylalanine (Trp-Phe). H-Trp-Phe-OH is also an antihypertensive peptide with inhibitory activity on angiotensin-converting enzyme (ACE), dose-dependently increases NO levels, and decreases endothelin-1 (ET-1) levels. H-Trp-Phe-OH (2 mg/kg; subcutaneous injection; 6 injections over 3 days) causes an increase in ovarian weight in female mice[1][2].

 Names

Name Trp-Phe
Synonym More Synonyms

 H-Trp-Phe-OH Biological Activity

Description H-Trp-Phe-OH is a dipeptide consisting of tryptophan and phenylalanine (Trp-Phe). H-Trp-Phe-OH is also an antihypertensive peptide with inhibitory activity on angiotensin-converting enzyme (ACE), dose-dependently increases NO levels, and decreases endothelin-1 (ET-1) levels. H-Trp-Phe-OH (2 mg/kg; subcutaneous injection; 6 injections over 3 days) causes an increase in ovarian weight in female mice[1][2].
Related Catalog
References

[1]. Zhao YQ, et al. Eight antihypertensive peptides from the protein hydrolysate of Antarctic krill (Euphausia superba): Isolation, identification, and activity evaluation on human umbilical vein endothelial cells (HUVECs). Food Res Int. 2019 Jul;121:197-204.  

[2]. Pitkow et al. Pharmacological effect of dipeptides on ovarian and uterine weights in immature mice. IRCS Medical Science: Library Compendium (1977), 5(8), 378.

 Chemical & Physical Properties

Density 1.319g/cm3
Boiling Point 688.3ºC at 760 mmHg
Molecular Formula C20H21N3O3
Molecular Weight 351.39900
Flash Point 370.1ºC
Exact Mass 351.15800
PSA 108.21000
LogP 2.94100
Index of Refraction 1.671

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AY7582000
CHEMICAL NAME :
Alanine, 3-phenyl-N-tryptophyl-, L-
CAS REGISTRY NUMBER :
6686-02-8
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H21-N3-O3
MOLECULAR WEIGHT :
351.44
WISWESSER LINE NOTATION :
T56 BMJ D1YZVMYVQ1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
150 mg/kg
SEX/DURATION :
female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
BIRSB5 Biology of Reproduction, Supplement. (Champaign, IL) No.1-4, 1969-71(?). Discontinued. For publisher information, see BIREBV. Volume(issue)/page/year: 20(Suppl 1),133A,1979

 Safety Information

HS Code 2933990090

 Precursor & DownStream

Precursor  0

DownStream  1

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2-[[2-amino-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoic acid
L-tryptophyl-L-Phenylalanine
tryptophyl-L-phenylalanine
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