Fosmidomycin sodium salt

Modify Date: 2024-01-06 10:39:35

Fosmidomycin sodium salt Structure
Fosmidomycin sodium salt structure
 Common Name Fosmidomycin sodium salt
CAS Number 66508-37-0 Molecular Weight 205.08
Density N/A Boiling Point 463.7ºC at 760 mmHg
Molecular Formula C4H9NNaO5P Melting Point 189-191ºC
MSDS N/A Flash Point 234.3ºC

 Use of Fosmidomycin sodium salt


Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial drug, which is active against both Gram-negative and Gram-positive bacteria.

 Names

Name Fosmidomycin Sodium Salt
Synonym More Synonyms

 Fosmidomycin sodium salt Biological Activity

Description Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial drug, which is active against both Gram-negative and Gram-positive bacteria.
Related Catalog
In Vitro Fosmidomycin sodium salt is a phosphonic acid antibiotic[1][2], which is active against both Gram-negative and Gram-positive bacteria[3].
In Vivo Animals treated intraperitoneally with dosages of >10 mg/kg of fosmidomycin are apparently free of parasites. After treatment with 5 mg/kg of fosmidomycin, parasitemias are <1%. Animals treated orally with 50 or 100 mg/kg of fosmidomycin are apparently free of parasites, and parasitemias are <1% after treatment with 20 mg/kg of drug. Recrudescence is observed when the treatment is terminated after 4 days. Mice treated with 30 mg/kg of fosmidomycin over a period of 8 days are totally cured[3].
References

[1]. Kojo H, et al. FR-31564, a new phosphonic acid antibiotic: bacterial resistance and membrane permeability. J Antibiot (Tokyo). 1980 Jan;33(1):44-8.

[2]. Fernandes JF, et al. Fosmidomycin as an antimalarial drug: a meta-analysis of clinical trials. Future Microbiol. 2015;10(8):1375-90.

[3]. Jomaa H, et al. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science. 1999 Sep 3;285(5433):1573-6.

 Chemical & Physical Properties

Boiling Point 463.7ºC at 760 mmHg
Melting Point 189-191ºC
Molecular Formula C4H9NNaO5P
Molecular Weight 205.08
Flash Point 234.3ºC
PSA 82.70000
LogP 0.34710
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SZ8554000
CHEMICAL NAME :
Phosphonic acid, (3-(formylhydroxyamino)propyl)-, monosodium salt
CAS REGISTRY NUMBER :
66508-37-0
LAST UPDATED :
199512
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C4-H9-N-O5-P.Na
MOLECULAR WEIGHT :
205.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>11 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #78-40720
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #78-40720
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>11 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #78-40720
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8050 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #78-40720
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 19(5),668,1985

 Safety Information

HS Code 2931900090

 Synthetic Route

dibenzyl (3-(N-(benzyloxy)formamido)propyl)phosphonate structure

dibenzyl (3-(N-...

CAS#:1417822-59-3

~39%

Fosmidomycin sodium salt Structure

Fosmidomycin so...

CAS#:66508-37-0
Literature: Suresh, Surisetti; Shyamraj, Dharavath; Larhed, Mats Tetrahedron, 2013 , vol. 69, # 3 p. 1183 - 1188
Formic Acid structure

Formic Acid

CAS#:64-18-6
3-( Hydroxyamino )propylphosphonic acid structure

3-( Hydroxyamin...

CAS#:66508-11-0

~%

Fosmidomycin sodium salt Structure

Fosmidomycin so...

CAS#:66508-37-0
Literature: US6680308 B1, ; Page column 15, 16 ;
3-( Hydroxyamino )propylphosphonic acid structure

3-( Hydroxyamin...

CAS#:66508-11-0
5-methyl-2-sulfanylidene-1,3,4-thiadiazole-3-carbaldehyde structure

5-methyl-2-sulf...

CAS#:100747-87-3

~95%

Fosmidomycin sodium salt Structure

Fosmidomycin so...

CAS#:66508-37-0
Literature: Yazawa, Hisatoyo; Goto, Shunsuke Tetrahedron Letters, 1985 , vol. 26, # 31 p. 3703 - 3706
3-( Hydroxyamino )propylphosphonic acid structure

3-( Hydroxyamin...

CAS#:66508-11-0
Formyl acetate structure

Formyl acetate

CAS#:2258-42-6

~68%

Fosmidomycin sodium salt Structure

Fosmidomycin so...

CAS#:66508-37-0
Literature: Hemmi; Takeno; Hashimoto; Kamiya Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 1 p. 111 - 118
fosmidomycin structure

fosmidomycin

CAS#:66508-53-0

~%

Fosmidomycin sodium salt Structure

Fosmidomycin so...

CAS#:66508-37-0
Literature: Suresh, Surisetti; Shyamraj, Dharavath; Larhed, Mats Tetrahedron, 2013 , vol. 69, # 3 p. 1183 - 1188
3-( Hydroxyamino )propylphosphonic acid structure

3-( Hydroxyamin...

CAS#:66508-11-0

~%

Fosmidomycin sodium salt Structure

Fosmidomycin so...

CAS#:66508-37-0
Literature: US4206156 A1, ;

 Customs

HS Code 2931900090
Summary 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Sodium hydrogen [(2S,3R)-3-methyl-2-oxiranyl]phosphonate
sodium,3-[formyl(hydroxy)amino]propyl-hydroxyphosphinate
Phosphonic acid, [(2S,3R)-3-methyloxiranyl]-, sodium salt (1:1)
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Chemsrc provides Fosmidomycin sodium salt(CAS#:66508-37-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Fosmidomycin sodium salt are included as well.>> amp version: Fosmidomycin sodium salt

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