(5aS,1aS)-5,5aα,6,6aα,7,7aα,7b,7cβ-Octahydro-4,7bβ-dimethyl-6-methylene-3H-cycloprop[2,3]oxireno[4,5]indeno[5,6-b]furan-3-one

Modify Date: 2024-01-08 22:24:52

(5aS,1aS)-5,5aα,6,6aα,7,7aα,7b,7cβ-Octahydro-4,7bβ-dimethyl-6-methylene-3H-cycloprop[2,3]oxireno[4,5]indeno[5,6-b]furan-3-one structure	Common Name	(5aS,1aS)-5,5aα,6,6aα,7,7aα,7b,7cβ-Octahydro-4,7bβ-dimethyl-6-methylene-3H-cycloprop[2,3]oxireno[4,5]indeno[5,6-b]furan-3-one
	CAS Number	66395-03-7	Molecular Weight	244.28600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₆O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (5aS,1aS)-5,5aα,6,6aα,7,7aα,7b,7cβ-Octahydro-4,7bβ-dimethyl-6-methylene-3H-cycloprop[2,3]oxireno[4,5]indeno[5,6-b]furan-3-one

Chloranthalactone B, a lindenane-type sesquiterpenoid, is a nature product that could be isolated from Chinese medicinal herb Sarcandra glabra. Chloranthalactone B inhibits the production of inflammatory mediators by inhibiting the AP-1 and p38 MAPK pathways[1].

Name	chloranthalactone B

Description	Chloranthalactone B, a lindenane-type sesquiterpenoid, is a nature product that could be isolated from Chinese medicinal herb Sarcandra glabra. Chloranthalactone B inhibits the production of inflammatory mediators by inhibiting the AP-1 and p38 MAPK pathways[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> Immunology/Inflammation >> NO Synthase Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
In Vitro	Chloranthalactone B (6.25-50 µM; 30 min) 在 LPS 刺激的 RAW264.7 细胞中具有抗炎作用并抑制 NO 产生[1]。 Chloranthalactone B (25 and 50 µM; 30 min) 抑制 LPS 处理的 RAW264.7 细胞中诱导型一氧化氮合酶 (iNOS)、环氧合酶-2 (COX-2)、肿瘤坏死因子 α (TNF-α) 和白介素-1β (IL-1β) 在细胞中的表达[1]。 Chloranthalactone B (25 and 50 µM; RAW264.7 细胞) 以浓度依赖性方式抑制 LPS 诱导的 AP-1 激活[1]。 Chloranthalactone B (25 and 50 µM; RAW264.7 细胞) 抑制 RAW264.7 细胞中 ERK、JNK 和 p38 的磷酸化[1]。 Western Blot Analysis[1] Cell Line: RAW264.7 cells Concentration: 25 and 50 µM Incubation Time: 30 min Result: Inhibited the expression of iNOS, TNF-α, COX-2, and IL-1β in a dose-dependent manner. Inhibited the phosphorylation of ERK, JNK, and p38 in RAW264.7 cells.
References	[1]. Li X, et, al. Anti-Inflammatory Effects of Chloranthalactone B in LPS-Stimulated RAW264.7 Cells. Int J Mol Sci. 2016 Nov 22;17(11):1938.

Molecular Formula	C₁₅H₁₆O₃
Molecular Weight	244.28600
Exact Mass	244.11000
PSA	38.83000
LogP	2.18690

(5aS,1aS)-5,5aα,6,6aα,7,7aα,7b,7cβ-Octahydro-4,7bβ-dimethyl-6-methylene-3H-cycloprop[2,3]oxireno[4,5]indeno[5,6-b]furan-3-one

Use of (5aS,1aS)-5,5aα,6,6aα,7,7aα,7b,7cβ-Octahydro-4,7bβ-dimethyl-6-methylene-3H-cycloprop[2,3]oxireno[4,5]indeno[5,6-b]furan-3-one

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