66395-03-7
66395-03-7 structure
- Name: (5aS,1aS)-5,5aα,6,6aα,7,7aα,7b,7cβ-Octahydro-4,7bβ-dimethyl-6-methylene-3H-cycloprop[2,3]oxireno[4,5]indeno[5,6-b]furan-3-one
- Chemical Name: chloranthalactone B
- CAS Number: 66395-03-7
- Molecular Formula: C15H16O3
- Molecular Weight: 244.28600
- Catalog: Signaling Pathways Immunology/Inflammation COX
- Create Date: 2018-01-23 13:22:13
- Modify Date: 2024-01-08 22:24:52
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Chloranthalactone B, a lindenane-type sesquiterpenoid, is a nature product that could be isolated from Chinese medicinal herb Sarcandra glabra. Chloranthalactone B inhibits the production of inflammatory mediators by inhibiting the AP-1 and p38 MAPK pathways[1].
| Name | chloranthalactone B |
|---|
| Description | Chloranthalactone B, a lindenane-type sesquiterpenoid, is a nature product that could be isolated from Chinese medicinal herb Sarcandra glabra. Chloranthalactone B inhibits the production of inflammatory mediators by inhibiting the AP-1 and p38 MAPK pathways[1]. |
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| Related Catalog | |
| In Vitro | Chloranthalactone B (6.25-50 µM; 30 min) 在 LPS 刺激的 RAW264.7 细胞中具有抗炎作用并抑制 NO 产生[1]。 Chloranthalactone B (25 and 50 µM; 30 min) 抑制 LPS 处理的 RAW264.7 细胞中诱导型一氧化氮合酶 (iNOS)、环氧合酶-2 (COX-2)、肿瘤坏死因子 α (TNF-α) 和白介素-1β (IL-1β) 在细胞中的表达[1]。 Chloranthalactone B (25 and 50 µM; RAW264.7 细胞) 以浓度依赖性方式抑制 LPS 诱导的 AP-1 激活[1]。 Chloranthalactone B (25 and 50 µM; RAW264.7 细胞) 抑制 RAW264.7 细胞中 ERK、JNK 和 p38 的磷酸化[1]。 Western Blot Analysis[1] Cell Line: RAW264.7 cells Concentration: 25 and 50 µM Incubation Time: 30 min Result: Inhibited the expression of iNOS, TNF-α, COX-2, and IL-1β in a dose-dependent manner. Inhibited the phosphorylation of ERK, JNK, and p38 in RAW264.7 cells. |
| References |
| Molecular Formula | C15H16O3 |
|---|---|
| Molecular Weight | 244.28600 |
| Exact Mass | 244.11000 |
| PSA | 38.83000 |
| LogP | 2.18690 |