Biotin-PEG4-amine

Modify Date: 2024-01-06 14:31:45

Biotin-PEG4-amine Structure
Biotin-PEG4-amine structure
Common Name Biotin-PEG4-amine
CAS Number 663171-32-2 Molecular Weight 462.604
Density 1.2±0.1 g/cm3 Boiling Point 724.4±60.0 °C at 760 mmHg
Molecular Formula C20H38N4O6S Melting Point N/A
MSDS N/A Flash Point 391.9±32.9 °C

 Use of Biotin-PEG4-amine


Biotin-PEG4-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name N-(14-Amino-3,6,9,12-tetraoxatetradec-1-yl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
Synonym More Synonyms

 Biotin-PEG4-amine Biological Activity

Description Biotin-PEG4-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 724.4±60.0 °C at 760 mmHg
Molecular Formula C20H38N4O6S
Molecular Weight 462.604
Flash Point 391.9±32.9 °C
Exact Mass 462.251190
LogP -2.14
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.514

 Synonyms

1H-Thieno[3,4-d]imidazole-4-pentanamide, N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)hexahydro-2-oxo-, (3aS,4S,6aR)-
MFCD26142992
N-(14-Amino-3,6,9,12-tetraoxatetradec-1-yl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide