1458576-00-5

1458576-00-5 structure

Name: Biotin-PEG4-alkyne
Chemical Name: Acetylene-PEG4-biotin conjugate
CAS Number: 1458576-00-5
Molecular Formula: C₂₁H₃₅N₃O₆S
Molecular Weight: 457.58
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-11-17 23:33:36
Modify Date: 2025-08-25 22:38:06
Biotin-PEG4-alkyne is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Acetylene-PEG4-biotin conjugate

Description	Biotin-PEG4-alkyne is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.