3-amino-2-chloro-6-(trifluoromethyl)pyridine

Modify Date: 2025-08-25 17:44:41

3-amino-2-chloro-6-(trifluoromethyl)pyridine structure	Common Name	3-amino-2-chloro-6-(trifluoromethyl)pyridine
	CAS Number	65182-56-1	Molecular Weight	222.24200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₀N₂O	Melting Point	92-94ºC
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS05, GHS07	Signal Word	Danger

Use of 3-amino-2-chloro-6-(trifluoromethyl)pyridine

2-NP is a selective enhancer of STAT1 transcription. 2-NP can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells[1].

Name	6-(1H-1,8-naphthyridin-2-ylidene)cyclohexa-2,4-dien-1-one
Synonym	More Synonyms

Description	2-NP is a selective enhancer of STAT1 transcription. 2-NP can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> STAT
References	[1]. Lynch RA, et, al. A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells. Cancer Res. 2007 Feb 1;67(3):1254-61.

Melting Point	92-94ºC
Molecular Formula	C₁₄H₁₀N₂O
Molecular Weight	222.24200
Exact Mass	222.07900
PSA	46.01000
LogP	3.00240
Appearance of Characters	orange
Storage condition	room temp
Water Solubility	DMSO: ≥10mg/mL

MSDS(Chinese)

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H318
Precautionary Statements	P280-P305 + P351 + P338
Hazard Codes	Xn,T
Risk Phrases	22-41-36-25
Safety Phrases	26-39-45
RIDADR	NONH for all modes of transport
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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