1-((4-Nitrophenyl)sulfonyl)piperidine

Modify Date: 2024-01-10 09:43:17

1-((4-Nitrophenyl)sulfonyl)piperidine Structure
1-((4-Nitrophenyl)sulfonyl)piperidine structure
Common Name 1-((4-Nitrophenyl)sulfonyl)piperidine
CAS Number 64268-93-5 Molecular Weight 270.30500
Density 1.374g/cm3 Boiling Point 435.9ºC at 760 mmHg
Molecular Formula C11H14N2O4S Melting Point 166ºC
MSDS N/A Flash Point 217.4ºC

 Use of 1-((4-Nitrophenyl)sulfonyl)piperidine


VP-4509, an anti-methicillin‐resistant Staphylococcus aureus (MRSA) agent, with the MIC of 49.3 µM. VP-4509 also possesses high antibacterial activity towards gram-negative bacteria P. aeruginosa[1].

 Names

Name 1-((4-Nitrophenyl)sulfonyl)piperidine
Synonym More Synonyms

 1-((4-Nitrophenyl)sulfonyl)piperidine Biological Activity

Description VP-4509, an anti-methicillin‐resistant Staphylococcus aureus (MRSA) agent, with the MIC of 49.3 µM. VP-4509 also possesses high antibacterial activity towards gram-negative bacteria P. aeruginosa[1].
Related Catalog
References

[1]. Palchykov V, et, al. Antimicrobial action of arylsulfonamides bearing (aza)norbornane and related motifs: evaluation of new promising anti-MRSA agents. Medicinal Chemistry Research volume 31, pages284-292 (2022).

 Chemical & Physical Properties

Density 1.374g/cm3
Boiling Point 435.9ºC at 760 mmHg
Melting Point 166ºC
Molecular Formula C11H14N2O4S
Molecular Weight 270.30500
Flash Point 217.4ºC
Exact Mass 270.06700
PSA 91.58000
LogP 3.31130
Index of Refraction 1.592

 MSDS

Material Safety Data Sheet

Section1. Identification of the substance
1-[(4-Nitrophenyl)sulfonyl]piperidine
Product Name:
Synonyms:

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H315:Causes skin irritation
H319:Causes serious eye irritation
H335:May cause respiratory irritation
P261:Avoid breathing dust/fume/gas/mist/vapours/spray
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P302+P352:IF ON SKIN: Wash with soap and water
P321:Specific treatment (see on this label)
P405:Store locked up

Section3. Composition/information on ingredients.
1-[(4-Nitrophenyl)sulfonyl]piperidine
Ingredient name:
CAS number:64268-93-5

Section4. First aid measures
Immediately wash skin with copious amounts of water for at least 15 minutes while removing
Skin contact:
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Ingestion:

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels.

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Not specified
Appearance:
Boiling point:No data
Melting point:No data
Flash point:No data
Density:No data
Molecular formula:C11H14N2O4S
Molecular weight:270.3

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, sulfur oxides.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

HS Code 2935009090

 Synthetic Route

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1-((4-Nitrophenyl)sulfonyl)piperidine Structure

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CAS#:64268-93-5

Literature: US2006/84802 A1, ; Page/Page column 30 ; US 20060084802 A1

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CAS#:64268-93-5

Literature: Palakurthy, Nani Babu; Dev, Dharm; Rana, Shubhasmin; Nadimpally, Krishna Chaitanya; Mandal, Bhubaneswar European Journal of Organic Chemistry, 2013 , # 13 p. 2627 - 2633

~77%

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CAS#:64268-93-5

Literature: Mukaiyama, Teruaki; Kuroda, Kiichi; Aoki, Hidenori Chemistry Letters, 2005 , vol. 34, # 12 p. 1644 - 1645

~10%

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CAS#:64268-93-5

Literature: Kweon, Deok-Heon; Kim, Ho-Kyun; Kim, Jeum-Jong; Chung, Hyun A.; Woo, Song Lee; Kim, Sung-Kyu; Yoon, Yong-Jin Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 1 p. 203 - 211

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1-((4-Nitrophenyl)sulfonyl)piperidine Structure

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CAS#:64268-93-5

Literature: European Journal of Organic Chemistry, , # 13 p. 2627 - 2633

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1-((4-Nitrophenyl)sulfonyl)piperidine Structure

1-((4-Nitrophen...

CAS#:64268-93-5

Literature: Chemistry Letters, , vol. 34, # 12 p. 1644 - 1645

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1-((4-Nitrophenyl)sulfonyl)piperidine Structure

1-((4-Nitrophen...

CAS#:64268-93-5

Literature: Journal of Organic Chemistry, , vol. 69, # 9 p. 3166 - 3172

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1-((4-Nitrophenyl)sulfonyl)piperidine Structure

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CAS#:64268-93-5

Literature: Bulletin of the Korean Chemical Society, , vol. 31, # 1 p. 234 - 237

 Customs

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

 Synonyms

1-(4-nitrophenyl)sulfonylpiperidine