e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

N-Nitration of secondary amines with 4-chloro-5-methoxy-2-nitropyridazin-3-one

YD Park, HK Kim, JJ Kim, SD Cho, SK Kim…

Index: Kweon, Deok-Heon; Kim, Ho-Kyun; Kim, Jeum-Jong; Chung, Hyun A.; Woo, Song Lee; Kim, Sung-Kyu; Yoon, Yong-Jin Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 1 p. 203 - 211

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Citation Number: 20

Abstract

N-Nitration of 4-chloro-5-substituted-pyridazin-3-one with copper nitrate trihydrate in acetic anhydride gave the corresponding 4-chloro-2-nitro-5-substituted-pyridazin-3-one. 4-Chloro- 5-alkoxy-2-nitropyridazin-3-ones such as 5-methoxy (2b) and 5-ethoxy (2d) derivatives

4,5-Dichloro-3(2H)-pyridazinone Structure

4,5-Dichloro-3(...

Tosyl chloride Structure

~86%

4,5-dichloro-2-(4-methylphenyl)sulfonylpyridazin-3-one Structure

4,5-dichloro-2-...

4-Chlorobenzenesulfonyl chloride Structure

4-Chlorobenzene...

~%

1-(4-chlorophenyl)sulfonylpiperidine Structure

1-(4-chlorophen...

chlorophenylsulfone Structure

chlorophenylsulfone

~%

Benzenesulfonamide,N,N-diethyl- Structure

Benzenesulfonam...

nosyl chloride Structure

~%

Benzenesulfonamide,N-ethyl-4-nitro- Structure

Benzenesulfonam...

nosyl chloride Structure

~%

N,N-Diethyl-4-nitrobenzenesulfonamide Structure

N,N-Diethyl-4-n...

4,5-Dichloro-3(2H)-pyridazinone Structure

4,5-Dichloro-3(...

4-Chlorobenzenesulfonyl chloride Structure

4-Chlorobenzene...

~93%

4,5-dichloro-2-(4-chlorophenyl)sulfonylpyridazin-3-one Structure

4,5-dichloro-2-...

Piperidine Structure

4,5-dichloro-2-(4-methylphenyl)sulfonylpyridazin-3-one Structure

4,5-dichloro-2-...

~91%

1-(p-Tolylsulfonyl)piperidine Structure

1-(p-Tolylsulfo...

4,5-Dichloro-3(2H)-pyridazinone Structure

4,5-Dichloro-3(...

nosyl chloride Structure

~92%

4,5-dichloro-2-(4-nitrophenyl)sulfonyl-pyridazin-3-one Structure

4,5-dichloro-2-...

4,5-Dichloro-3(2H)-pyridazinone Structure

4,5-Dichloro-3(...

chlorophenylsulfone Structure

chlorophenylsulfone

~83%

2-(benzenesulfonyl)-4,5-dichloropyridazin-3-one Structure

2-(benzenesulfo...

4-Chlorobenzenesulfonyl chloride Structure

4-Chlorobenzene...

~%

4-chloro-N,N-diethylbenzenesulfonamide Structure

4-chloro-N,N-di...

o-Nitrophenylsulfonyl chloride Structure

o-Nitrophenylsu...

~%

Ethyl Sulfonamide Structure

Ethyl Sulfonamide

Piperidine Structure

4,5-dichloro-2-(4-nitrophenyl)sulfonyl-pyridazin-3-one Structure

4,5-dichloro-2-...

~10%

1-((4-Nitrophenyl)sulfonyl)piperidine Structure

1-((4-Nitrophen...