Disodium edetate dihydrate

Modify Date: 2025-08-20 16:53:02

Disodium edetate dihydrate Structure
Disodium edetate dihydrate structure
 Common Name Disodium edetate dihydrate
CAS Number 6381-92-6 Molecular Weight 372.237
Density 1.01 g/mL at 25 °C Boiling Point >100 °C
Molecular Formula C10H18N2Na2O10 Melting Point 250 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 325.2ºC
Symbol GHS07 GHS08
GHS07, GHS08		 Signal Word Warning

 Use of Disodium edetate dihydrate


Ethylenediaminetetraacetic acid (EDTA) disodium dihydrate is a chelating agent used as a protease inhibitor and metal ion scavenger. Ethylenediaminetetraacetic acid disodium dihydrate is used extensively during protein purification. Ethylenediaminetetraacetic acid disodium dihydrate has been shown to be a noneffective molecule on cellulase activity. Ethylenediaminetetraacetic acid disodium dihydrate binds to metals including calcium and facilitates their excretion[1][2].

 Names

Name EDTA disodium salt dihydrate
Synonym More Synonyms

 Disodium edetate dihydrate Biological Activity

Description Ethylenediaminetetraacetic acid (EDTA) disodium dihydrate is a chelating agent used as a protease inhibitor and metal ion scavenger. Ethylenediaminetetraacetic acid disodium dihydrate is used extensively during protein purification. Ethylenediaminetetraacetic acid disodium dihydrate has been shown to be a noneffective molecule on cellulase activity. Ethylenediaminetetraacetic acid disodium dihydrate binds to metals including calcium and facilitates their excretion[1][2].
Related Catalog
References

[1]. Ibad A, et al. Chelation therapy in the treatment of cardiovascular diseases. J Clin Lipidol. 2016;10(1):58-62.

[2]. Chumanov RS, et al. Artifact-inducing enrichment of ethylenediaminetetraacetic acid and ethyleneglycoltetraacetic acid on anion exchange resins. Anal Biochem. 2011;412(1):34-39.

 Chemical & Physical Properties

Density 1.01 g/mL at 25 °C
Boiling Point >100 °C
Melting Point 250 °C (dec.)(lit.)
Molecular Formula C10H18N2Na2O10
Molecular Weight 372.237
Flash Point 325.2ºC
Exact Mass 372.075684
PSA 179.80000
Index of Refraction n20/D 1.363
Storage condition 2-8°C
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AH4410000
CHEMICAL NAME :
Acetic acid, (ethylenedinitrilo)tetra-, disodium salt, dihydrate
CAS REGISTRY NUMBER :
6381-92-6
LAST UPDATED :
199504
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C10-H14-N2-O8.2Na.2H2-O
MOLECULAR WEIGHT :
372.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
200 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 163,63,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7050 No. of Facilities: 1244 (estimated) No. of Industries: 13 No. of Occupations: 20 No. of Employees: 12572 (estimated) No. of Female Employees: 8163 (estimated)

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H332-H373
Precautionary Statements P260
Target Organs Respiratory Tract
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi:Irritant
Risk Phrases R36/38
Safety Phrases S26-S61-S37/39-S36/37/39
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS AH4025000
HS Code 29224995

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

DISODIUM EDTA DIHYDRATE
Edetate disodium dihydrate
Ethylenediaminetetraacetic acid disodium salt dihydrate
Sodium 2,2'-{1,2-ethanediylbis[(carboxymethyl)imino]}diacetate hydrate (2:1:2)
edta
EDTA disodium salt dihydrate
Sodium 2,2'-{ethane-1,2-diylbis[(carboxymethyl)imino]}diacetate hydrate (2:1:2) (non-preferred name)
EDTA disodium dihydrate
EINECS 205-358-3
Disodium Dihydrogen Ethylenediaminetetraacetate Dihydrate
MFCD00003541
Disodium edetate dihydrate
EDTA-2Na
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