Disodium edetate dihydrate

Names

[ Name ]:
Disodium edetate dihydrate

[Synonym ]:
DISODIUM EDTA DIHYDRATE
Edetate disodium dihydrate
Ethylenediaminetetraacetic acid disodium salt dihydrate
Sodium 2,2'-{1,2-ethanediylbis[(carboxymethyl)imino]}diacetate hydrate (2:1:2)
edta
EDTA disodium salt dihydrate
Sodium 2,2'-{ethane-1,2-diylbis[(carboxymethyl)imino]}diacetate hydrate (2:1:2) (non-preferred name)
EDTA disodium dihydrate
EINECS 205-358-3
Disodium Dihydrogen Ethylenediaminetetraacetate Dihydrate
MFCD00003541
Disodium edetate dihydrate
EDTA-2Na

Biological Activity

[Description]:

Ethylenediaminetetraacetic acid (EDTA) disodium dihydrate is a chelating agent used as a protease inhibitor and metal ion scavenger. Ethylenediaminetetraacetic acid disodium dihydrate is used extensively during protein purification. Ethylenediaminetetraacetic acid disodium dihydrate has been shown to be a noneffective molecule on cellulase activity. Ethylenediaminetetraacetic acid disodium dihydrate binds to metals including calcium and facilitates their excretion[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Ibad A, et al. Chelation therapy in the treatment of cardiovascular diseases. J Clin Lipidol. 2016;10(1):58-62.

[2]. Chumanov RS, et al. Artifact-inducing enrichment of ethylenediaminetetraacetic acid and ethyleneglycoltetraacetic acid on anion exchange resins. Anal Biochem. 2011;412(1):34-39.

Chemical & Physical Properties

[ Density]:
1.01 g/mL at 25 °C

[ Boiling Point ]:
>100 °C

[ Melting Point ]:
250 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₀H₁₈N₂Na₂O₁₀

[ Molecular Weight ]:
372.237

[ Flash Point ]:
325.2ºC

[ Exact Mass ]:
372.075684

[ PSA ]:
179.80000

[ Index of Refraction ]:
n20/D 1.363

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AH4410000

CHEMICAL NAME :: Acetic acid, (ethylenedinitrilo)tetra-, disodium salt, dihydrate

CAS REGISTRY NUMBER :: 6381-92-6

LAST UPDATED :: 199504

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H14-N2-O8.2Na.2H2-O

MOLECULAR WEIGHT :: 372.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 200 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 163,63,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7050 No. of Facilities: 1244 (estimated) No. of Industries: 13 No. of Occupations: 20 No. of Employees: 12572 (estimated) No. of Female Employees: 8163 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H332-H373

[ Precautionary Statements ]:
P260

[ Target Organs ]:
Respiratory Tract

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/38

[ Safety Phrases ]:
S26-S61-S37/39-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
AH4025000

[ HS Code ]:
29224995

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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