4-Hydroxyisophthalic acid

Modify Date: 2024-01-03 09:23:57

4-Hydroxyisophthalic acid Structure
4-Hydroxyisophthalic acid structure
Common Name 4-Hydroxyisophthalic acid
CAS Number 636-46-4 Molecular Weight 182.130
Density 1.6±0.1 g/cm3 Boiling Point 447.5±40.0 °C at 760 mmHg
Molecular Formula C8H6O5 Melting Point >300°C
MSDS Chinese USA Flash Point 238.6±23.8 °C
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Names

Name 4-Hydroxyisophthalic acid
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 447.5±40.0 °C at 760 mmHg
Melting Point >300°C
Molecular Formula C8H6O5
Molecular Weight 182.130
Flash Point 238.6±23.8 °C
Exact Mass 182.021530
PSA 94.83000
LogP 2.09
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.666

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NT2544000
CHEMICAL NAME :
Isophthalic acid, 4-hydroxy-
CAS REGISTRY NUMBER :
636-46-4
BEILSTEIN REFERENCE NO. :
2211981
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C8-H6-O5
MOLECULAR WEIGHT :
182.14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1071 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 11,20,1956
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 16,200,1961 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
73500 mg/kg/14W-C
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 11,20,1956

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H302-H318
Precautionary Statements P280-P305 + P351 + P338
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36/37/39
RIDADR NONH for all modes of transport
RTECS NT2544000
HS Code 2918290000

 Synthetic Route

 Customs

HS Code 2918290000
Summary HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

 Articles5

More Articles
A catabolic plasmid involved in 4-methyl-o-phthalate and 4-hydroxy-iso-phthalate degradation in Pseudomonas cepacia.

FEMS Microbiol. Lett. 57(3) , 323-8, (1990)

Genes involved in 4-methyl-o-phthalate and 4-hydroxy-iso-phthalate catabolism reside on a 226-232 kbp catabolic plasmid termed MOP. This was confirmed by transformation and conjugation into an isogeni...

[In vitro study of the mechanism of the platelet anti-aggregant action of picotamide (G 137)].

Boll. Soc. Ital. Biol. Sper. 59(3) , 309-15, (1983)

[In vitro study of the effects of various 4-hydroxyisophthalic acid derivatives on human platelet aggregation].

Boll. Soc. Ital. Biol. Sper. 59(3) , 302-8, (1983)

 Synonyms

4-Hydroxyisophthalic acid
MFCD00010391
4-Hydroxy-1,3-benzenedecarboxylic acid
1,3-Benzenedicarboxylic acid, 4-hydroxy-
4-Hydroxybenzene-1,3-dicarboxylic acid
EINECS 211-258-0