benzo[a]pyrene-d12

Modify Date: 2024-01-05 17:26:13

benzo[a]pyrene-d12 structure	Common Name	benzo[a]pyrene-d12
	CAS Number	63466-71-7	Molecular Weight	264.38300
	Density	1.348 g/cm3	Boiling Point	495ºC(lit.)
	Molecular Formula	C₂₀D₁₂	Melting Point	177-180ºC(lit.)
	MSDS	Chinese USA	Flash Point	228.6ºC
	Symbol	GHS05, GHS07, GHS08, GHS09	Signal Word	Danger

Use of benzo[a]pyrene-d12

Benzo[a]pyrene-d12 is the deuterium labeled Benzo[a]pyrene[1]. Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies[2][3].

Name	1,2,3,4,5,6,7,8,9,10,11,12-dodecadeuteriobenzo[a]pyrene
Synonym	More Synonyms

Description	Benzo[a]pyrene-d12 is the deuterium labeled Benzo[a]pyrene[1]. Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies[2][3].
Related Catalog	Research Areas >> Cancer
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Saeko Onami, et al. Dosimetry for lung tumorigenesis induced by urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice. J Toxicol Pathol. 2017 Jul; 30(3): 209–216. [3]. Yeo CD, et al. Roflumilast treatment inhibits lung carcinogenesis in benzo(a)pyrene-induced murine lung cancer model. Eur J Pharmacol. 2017 Oct 5812:189

Density	1.348 g/cm3
Boiling Point	495ºC(lit.)
Melting Point	177-180ºC(lit.)
Molecular Formula	C₂₀D₁₂
Molecular Weight	264.38300
Flash Point	228.6ºC
Exact Mass	264.16900
LogP	5.73720
Storage condition	0-6°C

benzo[a]pyrene-d12 MSDS(Chinese)

Symbol	GHS05, GHS07, GHS08, GHS09
Signal Word	Danger
Hazard Statements	H317-H318-H340-H350-H360FD-H410
Precautionary Statements	P201-P280-P305 + P351 + P338 + P310-P308 + P313
Hazard Codes	T,N
Risk Phrases	R45
Safety Phrases	S45-S53-S60-S61
RIDADR	UN 3077 9/PG 3
WGK Germany	3

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Perdeuteriobenzo<a>pyren

3,4-Benzopyrene-d12

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: benzo[a]pyrene-d12
Price: ￥3148.0/10mg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

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