benzo[a]pyrene-d12

Names

[ Name ]:
benzo[a]pyrene-d12

[Synonym ]:
Perdeuteriobenzo<a>pyren
3,4-Benzopyrene-d12

Biological Activity

[Description]:

Benzo[a]pyrene-d12 is the deuterium labeled Benzo[a]pyrene[1]. Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies[2][3].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Saeko Onami, et al. Dosimetry for lung tumorigenesis induced by urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice. J Toxicol Pathol. 2017 Jul; 30(3): 209–216.

[3]. Yeo CD, et al. Roflumilast treatment inhibits lung carcinogenesis in benzo(a)pyrene-induced murine lung cancer model. Eur J Pharmacol. 2017 Oct 5812:189

Chemical & Physical Properties

[ Density]:
1.348 g/cm3

[ Boiling Point ]:
495ºC(lit.)

[ Melting Point ]:
177-180ºC(lit.)

[ Molecular Formula ]:
C₂₀D₁₂

[ Molecular Weight ]:
264.38300

[ Flash Point ]:
228.6ºC

[ Exact Mass ]:
264.16900

[ LogP ]:
5.73720

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H317-H318-H340-H350-H360FD-H410

[ Precautionary Statements ]:
P201-P280-P305 + P351 + P338 + P310-P308 + P313

[ Hazard Codes ]:
T,N

[ Risk Phrases ]:
R45

[ Safety Phrases ]:
S45-S53-S60-S61

[ RIDADR ]:
UN 3077 9/PG 3

[ WGK Germany ]:
3

Articles

Pollution biomonitoring in the Bizerte lagoon (Tunisia), using combined chemical and biomarker analyses in grass goby, Zosterisessor ophiocephalus (Teleostei, Gobiidae).

Mar. Environ. Res. 101 , 184-95, (2014)

In this study, biological responses and contaminant levels in biological tissues were investigated in grass goby fish specimens (Zosterisessor ophiocephalus) collected from five stations in a moderate...

Distribution and Sources of Petroleum Hydrocarbons in Recent Sediments of the Imo River, SE Nigeria.

Arch. Environ. Contam. Toxicol. 70 , 372-82, (2016)

The distribution of aliphatic and aromatic hydrocarbons in surface sediments of the lower course of the Imo River (Nigeria) was investigated to determine the sources and fate of these compounds. The a...

The effects of flow rate and temperature on SPMD measurements of bioavailable PAHs in seawater.

Mar. Pollut. Bull. 97 , 217-23, (2015)

This work investigates the dependence of the sampling rate (Rs) of semi-permeable membrane devices (SPMDs) on flow rate and temperature. The in situ Rs values were obtained using performance reference...