| Description |
SQ609 is a lead compound from a library of dipiperidines. SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells. SQ609 displays a potent antitubercular activity [1].
|
| Related Catalog |
|
| In Vitro |
In Mtb-infected macrophages in vitro, SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells[1].
|
| In Vivo |
SQ609 (10 mg/kg; intravenous injection) completely prevents weight loss in the Mtb-infected animals and prolongs the therapeutic effect following drug withdrawal for another 10-15 days[1]. Animal Model: TB susceptible mice (C3H/He)[1] Dosage: 10 mg/kg Administration: I.v. Result: Prevented weight loss in the Mtb-infected animals and prolonged the therapeutic effect following drug withdrawal for another 10-15 days.
|
| References |
[1]. Bogatcheva E, et al. Identification of SQ609 as a lead compound from a library of dipiperidines. Bioorg Med Chem Lett. 2011;21(18):5353-5357.
|
