| Description |
OMDM-3 is a selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a Ki of 16.6 μM[1].
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| Related Catalog |
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| Target |
Ki: 16.6 μM (anandamide cellular uptake)[1]
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| In Vitro |
OMDM-3 shows poor affinity for either CB1 (Ki=6.1 μM) or CB2 (Ki>10 μM) receptors in rat brain and spleen membranes, respectively. OMDM-3 has almost no activity at vanilloid receptors in the intracellular calcium assay carried out with intact cells over-expressing the human VR1 (EC50>10 μM), and no activity as inhibitors of FAAH in N18TG2 cell membranes (Ki>50 μM)[1].
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| References |
[1]. Ortar G, et al. Novel selective and metabolically stable inhibitors of anandamide cellular uptake. Biochem Pharmacol. 2003 May 1;65(9):1473-81.
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