protopine hydrochloride

Modify Date: 2024-01-14 19:36:03

protopine hydrochloride structure	Common Name	protopine hydrochloride
	CAS Number	6164-47-2	Molecular Weight	389.83
	Density	N/A	Boiling Point	547.5ºC at 760 mmHg
	Molecular Formula	C₂₀H₂₀ClNO₅	Melting Point	208ºC
	MSDS	Chinese USA	Flash Point	284.9ºC
	Symbol	GHS06	Signal Word	Danger

Use of protopine hydrochloride

Protopine hydrochloride, an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine hydrochloride exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity[1][2].

Name	protopine hydrochloride
Synonym	More Synonyms

Description	Protopine hydrochloride, an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine hydrochloride exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Neuronal Signaling >> AChE
References	[1]. Kim SR, et, al. Protopine from Corydalis ternata has anticholinesterase and antiamnesic activities. Planta Med. 1999 Apr;65(3):218-21. [2]. Nie C, et, al. Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma. Cancer Cell Int. 2021 Jul 27;21(1):396.

Description

Related Catalog

Research Areas >> Cancer

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Neuronal Signaling >> AChE

References

[1]. Kim SR, et, al. Protopine from Corydalis ternata has anticholinesterase and antiamnesic activities. Planta Med. 1999 Apr;65(3):218-21.

[2]. Nie C, et, al. Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma. Cancer Cell Int. 2021 Jul 27;21(1):396.

Boiling Point	547.5ºC at 760 mmHg
Melting Point	208ºC
Molecular Formula	C₂₀H₂₀ClNO₅
Molecular Weight	389.83
Flash Point	284.9ºC
Exact Mass	389.10300
PSA	57.23000
LogP	3.29720
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UL2000000

CHEMICAL NAME :: Protopine, hydrochloride

CAS REGISTRY NUMBER :: 6164-47-2

LAST UPDATED :: 199012

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H19-N-O5.Cl-H

MOLECULAR WEIGHT :: 389.86

WISWESSER LINE NOTATION :: T I5 G6 B-10-65 DN JO LO PV VO A&O KH WH&&T&&J D1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 104,253,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 36 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 5,163,1946

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T
Risk Phrases	25
Safety Phrases	36/37/39-45
RIDADR	UN 1544
RTECS	UL2000000
Packaging Group	III
Hazard Class	6.1(b)

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It was the aim of the present experiments to examine potential antidiabetic effects of the Cimicifuga racemosa extract Ze 450.Ze 450 and some of its components (23-epi-26-deoxyactein, protopine and ci...

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The purpose of the research was to investigate the multiple response optimizations for the extraction of protopine and allocryptopine from the stems of Macleaya cordata (Willd) R. Br. by using microwa...

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