Merck-22-6

Modify Date: 2024-01-08 17:28:02

Merck-22-6 structure	Common Name	Merck-22-6
	CAS Number	612847-42-4	Molecular Weight	653.81500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₀H₄₃N₇O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Merck-22-6

Akt1/Akt2-IN-2 (compound 7) is an allosteric dual Akt1 and Akt2 inhibitor (IC50=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells[1].

Name	N-[2-(diethylamino)ethyl]-3-[4-[[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-2-phenylquinoxaline-6-carboxamide

Description	Akt1/Akt2-IN-2 (compound 7) is an allosteric dual Akt1 and Akt2 inhibitor (IC50=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	Akt1:138 nM (IC50) Akt2:212 nM (IC50) Akt3:7.2 mM (IC50) Caspase-3
In Vitro	Akt1/Akt2-IN-2 (compound 7) 对 LnCaP，HT29，MCF7，A2780 细胞有细胞毒性[1]。 Akt1/Akt2-IN-2 (2 μM, 4 μM) 分别在2 μM和4 μM时，诱导 LnCaP 细胞中 caspase-3 的活性增加 3 倍或 6.6 倍[1]。
References	[1]. Zhao Z, et al. Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity. Bioorg Med Chem Lett. 2008 Jan 1;18(1):49-53.

Molecular Formula	C₄₀H₄₃N₇O₂
Molecular Weight	653.81500
Exact Mass	653.34800
PSA	102.90000
LogP	7.44050

2-aminoethyldiethylamine structure

2-aminoethyldie...

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3,4-Diaminobenzoicacid structure

3,4-Diaminobenz...

CAS#:619-05-6

1-(4-((4-(2-OXO-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOL-1-YL)PIPERIDIN-1-YL)METHYL)PHENYL)-2-PHENYLETHANE-1,2-DIONE structure

1-(4-((4-(2-OXO...

CAS#:612848-74-5

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Merck-22-6 Structure

Merck-22-6

CAS#:612847-42-4

Detail

Literature: Zhao, Zhijian; Robinson, Ronald G.; Barnett, Stanley F.; Defeo-Jones, Deborah; Jones, Raymond E.; Hartman, George D.; Huber, Hans E.; Duggan, Mark E.; Lindsley, Craig W. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 49 - 53

DC Chemicals Limited
China
Product Name: Merck-22-6
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Merck-22-6
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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