Merck-22-6
Names
[ CAS No. ]:
612847-42-4
[ Name ]:
Merck-22-6
Biological Activity
[Description]:
Akt1/Akt2-IN-2 (compound 7) is an allosteric dual Akt1 and Akt2 inhibitor (IC50=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells[1].
[Related Catalog]:
[Target]
Akt1:138 nM (IC50)
Akt2:212 nM (IC50)
Akt3:7.2 mM (IC50)
Caspase-3
[In Vitro]
Akt1/Akt2-IN-2 (compound 7) 对 LnCaP,HT29,MCF7,A2780 细胞有细胞毒性[1]。 Akt1/Akt2-IN-2 (2 μM, 4 μM) 分别在2 μM和4 μM时,诱导 LnCaP 细胞中 caspase-3 的活性增加 3 倍或 6.6 倍[1]。
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C40H43N7O2
[ Molecular Weight ]:
653.81500
[ Exact Mass ]:
653.34800
[ PSA ]:
102.90000
[ LogP ]:
7.44050