Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate

Modify Date: 2025-08-21 18:02:23

Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate Structure
Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate structure
Common Name Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate
CAS Number 6093-71-6 Molecular Weight 234.205
Density 1.4±0.1 g/cm3 Boiling Point 448.3±45.0 °C at 760 mmHg
Molecular Formula C12H10O5 Melting Point 170.0 to 174.0 °C
MSDS Chinese USA Flash Point 178.7±22.2 °C

 Use of Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate


Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM. Y29 also inhibits the HeLa cell growth with a GI50 of 2.7 µM[1].

 Names

Name ethyl 7-hydroxy-2-oxochromene-3-carboxylate
Synonym More Synonyms

  Biological Activity

Description Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM. Y29 also inhibits the HeLa cell growth with a GI50 of 2.7 µM[1].
Related Catalog
References

[1]. Minsuh Seo, et al. Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect. PLoS One. 2011;6(9):e24179.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 448.3±45.0 °C at 760 mmHg
Melting Point 170.0 to 174.0 °C
Molecular Formula C12H10O5
Molecular Weight 234.205
Flash Point 178.7±22.2 °C
Exact Mass 234.052826
PSA 76.74000
LogP 1.85
Appearance of Characters white to beige
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.598
Storage condition −20°C
Water Solubility DMSO: soluble5mg/mL, clear (warmed)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2932209090

 Synthetic Route

 Customs

HS Code 2932209090
Summary 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

3-carboethoxy-7-hydroxycoumarin
MFCD00017641
2H-1-Benzopyran-3-carboxylic acid, 7-hydroxy-2-oxo-, ethyl ester
7-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethyl ester
7-Hydroxycoumarin-3-carboxylic acid ethyl ester
ethyl 7-hydroxy-2-oxo-2H-[1]benzopyran-3-carboxylate
3-CARBETHOXYUMBELIFERONE
Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate
Ethyl 7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylate
ethyl 7-hydroxycoumarin-3-carboxylate
7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylic acid ethyl ester
7-HYDROXY-2-OXO-CHROMENE-3-CARBOXYLIC ACID ETHYL ESTER
YZ9
1gcz
3-carbethoxy-7-hydroxycoumarin
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