Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate

Modify Date: 2024-01-02 17:27:18

Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate structure	Common Name	Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate
	CAS Number	6093-71-6	Molecular Weight	234.205
	Density	1.4±0.1 g/cm3	Boiling Point	448.3±45.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₀O₅	Melting Point	170.0 to 174.0 °C
	MSDS	Chinese USA	Flash Point	178.7±22.2 °C

Use of Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate

Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM. Y29 also inhibits the HeLa cell growth with a GI50 of 2.7 µM[1].

Name	ethyl 7-hydroxy-2-oxochromene-3-carboxylate
Synonym	More Synonyms

Description	Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM. Y29 also inhibits the HeLa cell growth with a GI50 of 2.7 µM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Minsuh Seo, et al. Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect. PLoS One. 2011;6(9):e24179.

Density	1.4±0.1 g/cm3
Boiling Point	448.3±45.0 °C at 760 mmHg
Melting Point	170.0 to 174.0 °C
Molecular Formula	C₁₂H₁₀O₅
Molecular Weight	234.205
Flash Point	178.7±22.2 °C
Exact Mass	234.052826
PSA	76.74000
LogP	1.85
Appearance of Characters	white to beige
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.598
Storage condition	−20°C
Water Solubility	DMSO: soluble5mg/mL, clear (warmed)

MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2932209090

Precursor 8
CAS#:105-53-3 Diethyl malonate CAS#:95-01-2 b-Resorcylaldehyde CAS#:13209-77-3 ETHYL 7-ACETOXY... CAS#:105-56-6 Ethyl cyanoacetate
CAS#:87-13-8 Diethyl ethoxym... CAS#:108-46-3 Resorcine CAS#:105837-04-5 Ethyl 7-bromo-2... CAS#:22532-62-3 4-Bromo-2-hydro...
DownStream 10
CAS#:779-27-1 3-Carboxy-7-hyd... CAS#:86788-49-0 7-HYDROXY-2-OXO... CAS#:6093-73-8 7-propoxy-2H-ch... CAS#:13209-77-3 ETHYL 7-ACETOXY...
CAS#:20300-59-8 7-Methoxy-2-oxo... CAS#:79065-74-0 7-ethoxy-2-oxoc... CAS#:94108-86-8 7-hydroxy-2-oxo... CAS#:6093-72-7 Ethyl 7-methoxy...
CAS#:6093-74-9 CHEMBRDG-BB 5873913 CAS#:51867-62-0 3-chloroformyl-...

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3-carboethoxy-7-hydroxycoumarin

MFCD00017641

2H-1-Benzopyran-3-carboxylic acid, 7-hydroxy-2-oxo-, ethyl ester

7-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethyl ester

7-Hydroxycoumarin-3-carboxylic acid ethyl ester

ethyl 7-hydroxy-2-oxo-2H-[1]benzopyran-3-carboxylate

3-CARBETHOXYUMBELIFERONE

Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate

Ethyl 7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylate

ethyl 7-hydroxycoumarin-3-carboxylate

7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylic acid ethyl ester

7-HYDROXY-2-OXO-CHROMENE-3-CARBOXYLIC ACID ETHYL ESTER

YZ9

1gcz

3-carbethoxy-7-hydroxycoumarin

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate
Price: ￥288.0/50mg ￥848.0/250mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: YZ9
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-CARBETHOXYUMBELIFERONE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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