3'-bromo-5'-chloro-2'-hydroxyacetophenone

Modify Date: 2025-08-28 11:06:48

3'-bromo-5'-chloro-2'-hydroxyacetophenone structure	Common Name	3'-bromo-5'-chloro-2'-hydroxyacetophenone
	CAS Number	59443-15-1	Molecular Weight	249.48900
	Density	1.691g/cm3	Boiling Point	297.8ºC at 760 mmHg
	Molecular Formula	C₈H₆BrClO₂	Melting Point	100-103 °C(lit.)
	MSDS	Chinese USA	Flash Point	133.9ºC
	Symbol	GHS07	Signal Word	Warning

Name	3'-bromo-5'-chloro-2'-hydroxyacetophenone
Synonym	More Synonyms

Density	1.691g/cm3
Boiling Point	297.8ºC at 760 mmHg
Melting Point	100-103 °C(lit.)
Molecular Formula	C₈H₆BrClO₂
Molecular Weight	249.48900
Flash Point	133.9ºC
Exact Mass	247.92400
PSA	37.30000
LogP	3.01070
Index of Refraction	1.604

MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2914700090

5'-Chloro-2'-hy...

CAS#:1450-74-4

~95%

3'-bromo-5'-chl...

CAS#:59443-15-1

Literature: Patwari, Shivaji B.; Baseer, Mohammad A.; Vibhute, Yashwant B.; Bhusare, Sudhakar R. Tetrahedron Letters, 2003 , vol. 44, # 26 p. 4893 - 4894

Precursor 1
CAS#:1450-74-4 5'-Chloro-2'-hy...
DownStream 0

HS Code	2914700090
Summary	HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Inhibitors and promoters of tubulin polymerization: synthesis and biological evaluation of chalcones and related dienones as potential anticancer agents.

Bioorg. Med. Chem. 19(8) , 2659-65, (2011)

A series of dihalogenated chalcones and structurally related dienones were synthesized and evaluated for their antiproliferative activity in 10 different cancer cell lines and for their effect on micr...

Synthesis of 2-alkyl-substituted chromone derivatives using microwave irradiation.

J. Org. Chem. 74(7) , 2755-9, (2009)

A base-promoted condensation between 2-hydroxyacetophenones and aliphatic aldehydes has been studied. The reaction has been optimized to afford 2-alkyl-substituted 4-chromanones in an efficient manner...

Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitors.

J. Med. Chem. 55 , 7104-13, (2012)

A series of substituted chromone/chroman-4-one derivatives has been synthesized and evaluated as novel inhibitors of SIRT2, an enzyme involved in aging-related diseases, e.g., neurodegenerative disord...

MFCD00857068

1-(3-bromo-5-chloro-2-hydroxyphenyl)ethanone