3'-bromo-5'-chloro-2'-hydroxyacetophenone
Names
[ CAS No. ]:
59443-15-1
[ Name ]:
3'-bromo-5'-chloro-2'-hydroxyacetophenone
[Synonym ]:
MFCD00857068
1-(3-bromo-5-chloro-2-hydroxyphenyl)ethanone
Chemical & Physical Properties
[ Density]:
1.691g/cm3
[ Boiling Point ]:
297.8ºC at 760 mmHg
[ Melting Point ]:
100-103 °C(lit.)
[ Molecular Formula ]:
C8H6BrClO2
[ Molecular Weight ]:
249.48900
[ Flash Point ]:
133.9ºC
[ Exact Mass ]:
247.92400
[ PSA ]:
37.30000
[ LogP ]:
3.01070
[ Index of Refraction ]:
1.604
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ HS Code ]:
2914700090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2914700090
[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%
Articles
Bioorg. Med. Chem. 19(8) , 2659-65, (2011)
A series of dihalogenated chalcones and structurally related dienones were synthesized and evaluated for their antiproliferative activity in 10 different cancer cell lines and for their effect on micr...
Synthesis of 2-alkyl-substituted chromone derivatives using microwave irradiation.J. Org. Chem. 74(7) , 2755-9, (2009)
A base-promoted condensation between 2-hydroxyacetophenones and aliphatic aldehydes has been studied. The reaction has been optimized to afford 2-alkyl-substituted 4-chromanones in an efficient manner...
Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitors.J. Med. Chem. 55 , 7104-13, (2012)
A series of substituted chromone/chroman-4-one derivatives has been synthesized and evaluated as novel inhibitors of SIRT2, an enzyme involved in aging-related diseases, e.g., neurodegenerative disord...