Alizapride

Modify Date: 2024-01-02 12:17:15

Use of Alizapride

Alizapride is a potent antiemetic, acting as a dopamine receptor antagonist. Alizapride also used in human digestive disorders[1][3].

Name	N-((1-Allylpyrrolidin-2-yl)methyl)-6-methoxy-1H-benzo[d][1,2,3]triazole-5-carboxamide
Synonym	More Synonyms

Description	Alizapride is a potent antiemetic, acting as a dopamine receptor antagonist. Alizapride also used in human digestive disorders[1][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	Dopamine 2 receptor
In Vivo	Alizapride (2.5, 5, 10, 25 μg/kg; SC; 7 consecutive days) significantly reduces the bound IgG-sensitized erythrocytes with Splenic macrophages isolated from animals[2]. Animal Model: Male Duncan–Hartley guinea pigs[2] Dosage: 2.5, 5, 10, 25 μg/kg Administration: Alizapride (2.5, 5, 10, 25 μg/kg; SC; 7 consecutive days) Result: Reduced the clearance of IgG-sensitized RBCs.
References	[1]. P L Warzee, et al. Manometric study of the activity of alizapride on the motor function of the human sphincter of Oddi. J Clin Pharm Ther. 1988 Aug;13(4):281-4. [2]. Gomez, et al. Macrophage Fcgamma receptors expression is altered by treatment with dopaminergic drugs. Clinical immunology (Orlando, Fla.) vol. 90,3 (1999): 375-87. [3]. Seng, et al. Anti-emetic effect of high-dose metoclopramide vs alizapride--a randomised crossover study. British journal of clinical pharmacology vol. 38,3 (1994): 282-4.

CHEMICAL NAME :: 1H-Benzotriazole-5-carboxamide, 6-methoxy-N-((1-(2-propenyl)-2-pyrrolidinyl)methyl)-

TOXIC EFFECTS :: Behavioral - headache Vascular - BP elevation not characterized in autonomic section

REFERENCE :: NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 312,1125,1985

WGK Germany	3
HS Code	2933990090

Precursor 0
DownStream 1
CAS#:59338-92-0 6-Methoxy-1H-be...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

6-methoxy-N-[(1-prop-2-enylpyrrolidin-2-yl)methyl]-2H-benzotriazole-5-carboxamide

EINECS 261-710-6

MFCD00867757

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Price: ￥2730/1g

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