Tilomisole

Modify Date: 2024-01-03 07:39:28

Tilomisole structure	Common Name	Tilomisole
	CAS Number	58433-11-7	Molecular Weight	342.79900
	Density	1.51g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₁ClN₂O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Tilomisole

Tilomisole (Wy 18251) is a benzimidazothiazole experimental drug with anti-inflammatory activity. Tilomisole causes less agranulocytosis than levamisole, but retains immunomodulating capabilities. Tilomisole is orally active. Tilomisole has the potential for the research of cancer and inflammation[1][2].

Name	2-[1-(4-chlorophenyl)-[1,3]thiazolo[3,2-a]benzimidazol-2-yl]acetic acid
Synonym	More Synonyms

Description	Tilomisole (Wy 18251) is a benzimidazothiazole experimental drug with anti-inflammatory activity. Tilomisole causes less agranulocytosis than levamisole, but retains immunomodulating capabilities. Tilomisole is orally active. Tilomisole has the potential for the research of cancer and inflammation[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Dillman RO, et al. WY 18,251 (Tilomisole), an analog of levamisole: tolerability, and immune modulating effects in cancer patients. Mol Biother. 1992;4(1):10-14. [2]. Darwish SA, et al. New tilomisole-based benzimidazothiazole derivatives as anti-inflammatory agents: Synthesis, in vivo, in vitro evaluation, and in silico studies [published online ahead of print, 2022 Jan 29]. Bioorg Chem. 2022;120:105644.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

References

[1]. Dillman RO, et al. WY 18,251 (Tilomisole), an analog of levamisole: tolerability, and immune modulating effects in cancer patients. Mol Biother. 1992;4(1):10-14.

[2]. Darwish SA, et al. New tilomisole-based benzimidazothiazole derivatives as anti-inflammatory agents: Synthesis, in vivo, in vitro evaluation, and in silico studies [published online ahead of print, 2022 Jan 29]. Bioorg Chem. 2022;120:105644.

Density	1.51g/cm3
Molecular Formula	C₁₇H₁₁ClN₂O₂S
Molecular Weight	342.79900
Exact Mass	342.02300
PSA	82.84000
LogP	4.49650
Index of Refraction	1.746

N/A

CAS#:39481-06-6

~91%

Tilomisole

CAS#:58433-11-7

Literature: John Wyeth and Brother Ltd.; American Home Products Corporation Patent: US4812574 A1, 1989 ;

Aqueous ammonia

CAS#:1336-21-6

Sulfuric acid

CAS#:7664-93-9

N/A

CAS#:39481-06-6

Tilomisole

CAS#:58433-11-7

Literature: John Wyeth and Brother Ltd.; American Home Products Corporation Patent: US4812574 A1, 1989 ;

3-(p-Chlorophen...

CAS#:39225-26-8

Tilomisole

CAS#:58433-11-7