Tilomisole

Names

[ Name ]:
Tilomisole

[Synonym ]:
Tilomisol
Tilomisol [Spanish]
Tilomisole (USAN/INN)
Tilomisolum
3 (4 chlorophenyl)thiazolo[3,2 a]benzimidazole 2 acetic acid
3-(p-chlorophenyl)-thiazolo[3,2-a]benzimidazole-2-acetic acid
Tilomisolum [Latin]
[3-(4-chloro-phenyl)-benzo[4,5]imidazo[2,1-b]thiazol-2-yl]-acetic acid
TILOMISOLE

Biological Activity

[Description]:

Tilomisole (Wy 18251) is a benzimidazothiazole experimental drug with anti-inflammatory activity. Tilomisole causes less agranulocytosis than levamisole, but retains immunomodulating capabilities. Tilomisole is orally active. Tilomisole has the potential for the research of cancer and inflammation[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Dillman RO, et al. WY 18,251 (Tilomisole), an analog of levamisole: tolerability, and immune modulating effects in cancer patients. Mol Biother. 1992;4(1):10-14.

[2]. Darwish SA, et al. New tilomisole-based benzimidazothiazole derivatives as anti-inflammatory agents: Synthesis, in vivo, in vitro evaluation, and in silico studies [published online ahead of print, 2022 Jan 29]. Bioorg Chem. 2022;120:105644.

Chemical & Physical Properties

[ Density]:
1.51g/cm3

[ Molecular Formula ]:
C₁₇H₁₁ClN₂O₂S

[ Molecular Weight ]:
342.79900

[ Exact Mass ]:
342.02300

[ PSA ]:
82.84000

[ LogP ]:
4.49650

[ Index of Refraction ]:
1.746

Synthetic Route

Click to get detail synthetic route

Related Compounds

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