58433-11-7

58433-11-7 structure

Name: Tilomisole
Chemical Name: 2-[1-(4-chlorophenyl)-[1,3]thiazolo[3,2-a]benzimidazol-2-yl]acetic acid
CAS Number: 58433-11-7
Molecular Formula: C₁₇H₁₁ClN₂O₂S
Molecular Weight: 342.79900
Catalog: Research Areas Cancer
Create Date: 2018-04-25 08:00:00
Modify Date: 2025-08-27 18:24:09
Tilomisole (Wy 18251) is a benzimidazothiazole experimental drug with anti-inflammatory activity. Tilomisole causes less agranulocytosis than levamisole, but retains immunomodulating capabilities. Tilomisole is orally active. Tilomisole has the potential for the research of cancer and inflammation[1][2].

Name	2-[1-(4-chlorophenyl)-[1,3]thiazolo[3,2-a]benzimidazol-2-yl]acetic acid
Synonyms	Tilomisol Tilomisol [Spanish] Tilomisole (USAN/INN) Tilomisolum 3 (4 chlorophenyl)thiazolo[3,2 a]benzimidazole 2 acetic acid 3-(p-chlorophenyl)-thiazolo[3,2-a]benzimidazole-2-acetic acid Tilomisolum [Latin] [3-(4-chloro-phenyl)-benzo[4,5]imidazo[2,1-b]thiazol-2-yl]-acetic acid TILOMISOLE

Description	Tilomisole (Wy 18251) is a benzimidazothiazole experimental drug with anti-inflammatory activity. Tilomisole causes less agranulocytosis than levamisole, but retains immunomodulating capabilities. Tilomisole is orally active. Tilomisole has the potential for the research of cancer and inflammation[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Dillman RO, et al. WY 18,251 (Tilomisole), an analog of levamisole: tolerability, and immune modulating effects in cancer patients. Mol Biother. 1992;4(1):10-14. [2]. Darwish SA, et al. New tilomisole-based benzimidazothiazole derivatives as anti-inflammatory agents: Synthesis, in vivo, in vitro evaluation, and in silico studies [published online ahead of print, 2022 Jan 29]. Bioorg Chem. 2022;120:105644.

39481-06-6

~91%

58433-11-7

Literature: John Wyeth and Brother Ltd.; American Home Products Corporation Patent: US4812574 A1, 1989 ;

1336-21-6

7664-93-9

39481-06-6

58433-11-7

Literature: John Wyeth and Brother Ltd.; American Home Products Corporation Patent: US4812574 A1, 1989 ;