Isepamicin

Modify Date: 2025-08-21 12:27:55

Isepamicin structure	Common Name	Isepamicin
	CAS Number	58152-03-7	Molecular Weight	569.603
	Density	1.5±0.1 g/cm3	Boiling Point	926.8±65.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₄₃N₅O₁₂	Melting Point	N/A
	MSDS	N/A	Flash Point	514.3±34.3 °C

Use of Isepamicin

Isepamicin (Sch 21420) is an aminoglycoside antibacterial. Isepamicin has better activity against strains producing type I 6'-acetyltransferase. Isepamicin’s antibacterial spectrum includes Enterobacteriaceae and staphylococci. Anaerobes, Neisseriaceae and streptococci are resistant. Isepamicin exhibits a strong concentration-dependent bactericidal effect, a long post-antibiotic effect (several hours) and induces adaptive resistance[1].

Name	Isepamicine
Synonym	More Synonyms

Description	Isepamicin (Sch 21420) is an aminoglycoside antibacterial. Isepamicin has better activity against strains producing type I 6'-acetyltransferase. Isepamicin’s antibacterial spectrum includes Enterobacteriaceae and staphylococci. Anaerobes, Neisseriaceae and streptococci are resistant. Isepamicin exhibits a strong concentration-dependent bactericidal effect, a long post-antibiotic effect (several hours) and induces adaptive resistance[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Tod M, et al. Clinical pharmacokinetics and pharmacodynamics of isepamicin. Clin Pharmacokinet. 2000;38(3):205-223.

Density	1.5±0.1 g/cm3
Boiling Point	926.8±65.0 °C at 760 mmHg
Molecular Formula	C₂₂H₄₃N₅O₁₂
Molecular Weight	569.603
Flash Point	514.3±34.3 °C
Exact Mass	569.290833
PSA	297.72000
LogP	-2.45
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.641

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WK1972000

CHEMICAL NAME :: D-Streptamine, O-6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(3-d eoxy-4-C-methyl-3- (methylamino)-beta-L-arabinopyranosyl-(1-6))-N(sup 1)-(3-amino-2-hydroxy-1-oxopropyl)- 2-deoxy-, (S)-

CAS REGISTRY NUMBER :: 58152-03-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C22-H43-N5-O12

MOLECULAR WEIGHT :: 569.70

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 330 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 29,543,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3150 mg/kg/21D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - urine volume increased Kidney, Ureter, Bladder - changes in bladder weight

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 33(Suppl 5),47,1985

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 5600 mg/kg/4W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Ear) - changes in vestibular functions Sense Organs and Special Senses (Ear) - changes in cochlear structure or function Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 33(Suppl 5),90,1985

Sisomicin

CAS#:32385-11-8

Isepamicin

CAS#:58152-03-7

Literature: Tetrahedron Letters, , vol. 46, # 4 p. 607 - 609

6-azido-2,3,4-t...

CAS#:42869-68-1

Isepamicin

CAS#:58152-03-7

Literature: Tetrahedron Letters, , vol. 46, # 4 p. 607 - 609

1-[(2-benzyloxy...

CAS#:845258-90-4

Isepamicin

CAS#:58152-03-7

Literature: Tetrahedron Letters, , vol. 46, # 4 p. 607 - 609

CAS#:556059-94-0

Isepamicin

CAS#:58152-03-7

Literature: Tetrahedron Letters, , vol. 46, # 4 p. 607 - 609

CAS#:845258-88-0

Isepamicin

CAS#:58152-03-7

Literature: Tetrahedron Letters, , vol. 46, # 4 p. 607 - 609

CAS#:66567-35-9

Isepamicin

CAS#:58152-03-7

Literature: Doktorov, Konstantin; Tarpanov, Velichko; Mechkarova, Pepa Synthetic Communications, 2007 , vol. 37, # 21 p. 3709 - 3718

3,6'-bis-N-benz...

CAS#:66567-23-5

Isepamicin

CAS#:58152-03-7

Literature: Synthetic Communications, , vol. 37, # 21 p. 3709 - 3718

Precursor 7
CAS#:32385-11-8 Sisomicin CAS#:42869-68-1 6-azido-2,3,4-t... CAS#:845258-90-4 1-[(2-benzyloxy... CAS#:556059-94-0
CAS#:845258-88-0 CAS#:66567-35-9 CAS#:66567-23-5 3,6'-bis-N-benz...
DownStream 0

UNII-G7K224460P

(2S)-3-Amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(6-amino-6-deoxy-α-D-glucopyranosyl)oxy]-2-{[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl]oxy}-3-hydroxycyclohexyl]-2-hydroxypropanamide

isepamicin

изепамицин

HAPA-B

ISEPAMICIN SULPHATE

propanamide, 3-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(6-amino-6-deoxy-α-D-glucopyranosyl)oxy]-2-[[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl]oxy]-3-hydroxycyclohexyl]-2-hydroxy-, (2S)-

Propanamide, 3-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(6-amino-6-deoxy-α-D-glucopyranosyl)oxy]-2-[[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl]oxy]-3-hydroxycyclohexyl]-2-hydroxy-, (2 S)-

Isepamycin

hapa-gentamycinb

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Isepamicin
Price: Check
Purity: 98.0%
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Isepamicin
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
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DC Chemicals Limited
China
Product Name: Isepamicin
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Isepamicin

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Precursor & DownStream

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.