Ac-Gly-Ala-Lys(Ac)-AMC

Modify Date: 2025-09-07 16:32:06

Ac-Gly-Ala-Lys(Ac)-AMC Structure
Ac-Gly-Ala-Lys(Ac)-AMC structure
 Common Name Ac-Gly-Ala-Lys(Ac)-AMC
CAS Number 577969-56-3 Molecular Weight 515.56
Density N/A Boiling Point N/A
Molecular Formula C25H33N5O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ac-Gly-Ala-Lys(Ac)-AMC


Ac-Gly-Ala-Lys(Ac)-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Gly-Ala-Lys(Ac)-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal[1].

 Names

Name acetyl-Gly-Ala-(N-acetyl-Lys)-AMC
Synonym More Synonyms

 Ac-Gly-Ala-Lys(Ac)-AMC Biological Activity

Description Ac-Gly-Ala-Lys(Ac)-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Gly-Ala-Lys(Ac)-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal[1].
Related Catalog
References

[1]. Ptacek J, et, al. Selectivity of Hydroxamate- and Difluoromethyloxadiazole-Based Inhibitors of Histone Deacetylase 6 In Vitro and in Cells. Int J Mol Sci. 2023 Mar 1;24(5):4720.  

 Chemical & Physical Properties

Molecular Formula C25H33N5O7
Molecular Weight 515.56
Exact Mass 515.23800
PSA 175.71000
LogP 2.10850
InChIKey SUCZARDVMMDJRT-YWZLYKJASA-N
SMILES CC(=O)NCCCCC(NC(=O)C(C)NC(=O)CNC(C)=O)C(=O)Nc1ccc2c(C)cc(=O)oc2c1

 Synonyms

AC-GLY-ALA-LYS(AC)-AMC
Ac-GAK(Ac)-AMC
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