Docusate sodium

Modify Date: 2024-01-01 22:12:52

Docusate sodium structure	Common Name	Docusate sodium
	CAS Number	577-11-7	Molecular Weight	444.558
	Density	1.1	Boiling Point	N/A
	Molecular Formula	C₂₀H₃₇NaO₇S	Melting Point	173-179 °C(lit.)
	MSDS	Chinese USA	Flash Point	199ºC
	Symbol	GHS05	Signal Word	Danger

Use of Docusate sodium

Docusate Sodium is a laxative used to treat constipation, for constipation due to the use of opiates it maybe used with a stimulant laxative, can be taken by mouth or rectally.

Name	Docusate sodium
Synonym	More Synonyms

Description	Docusate Sodium is a laxative used to treat constipation, for constipation due to the use of opiates it maybe used with a stimulant laxative, can be taken by mouth or rectally.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others

Density	1.1
Melting Point	173-179 °C(lit.)
Molecular Formula	C₂₀H₃₇NaO₇S
Molecular Weight	444.558
Flash Point	199ºC
Exact Mass	444.215759
PSA	118.18000
LogP	4.89030
Storage condition	2-8°C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	1.5 g/100 mL (25 ºC)

Docusate sodium MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WN0525000

CHEMICAL NAME :: Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt

CAS REGISTRY NUMBER :: 577-11-7

LAST UPDATED :: 199710

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C20-H38-O7-S.Na

MOLECULAR WEIGHT :: 445.63

WISWESSER LINE NOTATION :: 2Y2&3OVYSWQ1VO3Y2&2 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 82,377,1944

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St., Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.64- 1960- Volume(issue)/page/year: 34,99,1945

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,428,1949 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 13,469,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 590 mg/kg

TOXIC EFFECTS :: Vascular - structural changes in vessels

REFERENCE :: BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 7,161,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2643 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 1,89,1977/1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,428,1949 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 42 gm/kg/12W-C

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 9,159,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 gm/kg/30D-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,428,1949

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 84 mg/kg/24W-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 25,175,1943 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 8820 mg/kg

SEX/DURATION :: multigeneration

TOXIC EFFECTS :: Reproductive - Effects on Newborn - other postnatal measures or effects

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 15,53,1990 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83280 No. of Facilities: 3817 (estimated) No. of Industries: 53 No. of Occupations: 74 No. of Employees: 45527 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83280 No. of Facilities: 11668 (estimated) No. of Industries: 95 No. of Occupations: 100 No. of Employees: 180694 (estimated) No. of Female Employees: 49329 (estimated)

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H315-H318
Precautionary Statements	P280-P305 + P351 + P338 + P310
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S39-S37/39-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	WN0525000
HS Code	2914509090

Bis(2-ethylhexy...

CAS#:142-16-5

Docusate sodium

CAS#:577-11-7

Literature: US7981932 B2, ; Page/Page column 4 ;

Precursor 1
CAS#:142-16-5 Bis(2-ethylhexy...
DownStream 0

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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sbo

Octowet

Nikkol OTP 100

DOSS

Astrowet 608

DIOX

Dioctyl sodium sulfosuccinate

Docusate sodium salt

Gemtex SC 40

Nikkol OTP 100S

Sanseparer 100

Geropon SS-O 75

Rapisol B 90

nevax

Bis(ethylhexyl) ester of sodium sulfosuccinic acid

Pentex 99

Dioctyl ester of sodium sulfosuccinate

Empimin OP 70

Neocol YSK

Sunnol LDF 110

Aerosol OT 100

Di-(2-ethylhexyl) sodium sulfosuccinate

sv102

colace

Triton GR 5

Sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxo-2-butanesulfonate

Newcol 290M

Rapisol B 80

Rewopol SBDO 70

sodium bis(2-ethylhexyl) sulfosuccinate

Sulfobutanedioic acid 1,4-bis(2-ethylhexyl) ester sodium salt

Gemtex SC

Lumiten I-RA

Valsol OT

Bis(2-ethylhexyl)sodium sulfosuccinate

Rapisol A 30

Solusol

doxol

Neopelex OTP

Airrol OP

Newcol 291M

Lankropol KO 2

Triton GR 7M

Newkalgen EP 60P

Solovet

revac

Geropon DOS

Astrowet O 70PG

Dioctyl sulfosuccinate sodium salt

Marlinat DF 8

Astrowet O 75

Persol KMN 3

Monawet MO 70R

coprol

Nikkol OTP 75

Triton GR 7ME

Aerosol OT 75PG

Sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonate

Aerosol OT-S

Spilon 8

Jamylene

Sodium Di(2-ethylhexyl) Sulfosuccinate

Pelex OT

Empimin OT 75

Butanedioic acid, 2-sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt (1:1)

DSS

Rapisol A 80

Triton GR 5M

Succinate STD

Pelex OT-P

Sulfosuccinic Acid 1,4-Bis(2-ethylhexyl) Ester S-Sodium Salt

Genopur SB 1970J

Lutensit A-BO

Bis(2-ethylhexyl) Sulfosuccinate Sodium Salt

Lutensit A-BOS

Docusate sodium

Neocol P

Di(2-ethylhexyl)sulfosuccinic acid, sodium salt

sodium dioctyl sulfosuccinate

Manoxol

Newkalgen EP 70G

Surfonic DOS 75PG

BIS(2-ETHYLHEXYL) SULFOSUCCINATE, SODIUM SALT

Monawet M 085P

Pionin A 51B

Geropon WT 27

EINECS 209-406-4

NK-EP 70G

Warcowet 060

Drewfax 007

Aerosol OT 94

Newcol 291EG

AOT

Nonit

Sodium Docusate

Airrol CT 1

Isoprotanc

Manoxol OP

MFCD00012455

Monawet MO 70

Sanmorin OT 70N

Freetex OT

Rapisol B 30

KM 10-1610

Monawet MO 70E

Docusate (Sodium)

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Docusate sodium
Price: ￥348.0/500g ￥118.0/100g
Purity: 96.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Docusate Sodium
Price: $100.0/100mg $200.0/250mg $400.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Docusate sodium
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Dioctyl sulfosuccinate, sodium salt
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Docusate sodium suppliers

Price: $66/10mM*1mLinWater

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Docusate sodium

Use of Docusate sodium

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Docusate sodium Biological Activity

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MSDS

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HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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