3-METHYLGLUTACONIC ACID

Modify Date: 2025-08-25 21:57:09

3-METHYLGLUTACONIC ACID structure	Common Name	3-METHYLGLUTACONIC ACID
	CAS Number	5746-90-7	Molecular Weight	144.13
	Density	1.307g/cm3	Boiling Point	399.4ºC at 760mmHg
	Molecular Formula	C₆H₈O₄	Melting Point	101 - 105°C (lit.)
	MSDS	N/A	Flash Point	209.5ºC

Use of 3-METHYLGLUTACONIC ACID

3-Methylglutaconic acid is the major metabolites accumulating in 3-Methylglutaconic aciduria (MGTA). 3-Methylglutaconic acid can induce lipid oxidative damage and protein oxidative. 3-Methylglutaconic acid decreases the non-enzymatic antioxidant defenses in cerebral cortex supernatants to elicit oxidative stress in the cerebral cortex. 3-Methylglutaconic acid can be used for brain damage disease research[1].

Name	3-methylglutaconic acid
Synonym	More Synonyms

Description	3-Methylglutaconic acid is the major metabolites accumulating in 3-Methylglutaconic aciduria (MGTA). 3-Methylglutaconic acid can induce lipid oxidative damage and protein oxidative. 3-Methylglutaconic acid decreases the non-enzymatic antioxidant defenses in cerebral cortex supernatants to elicit oxidative stress in the cerebral cortex. 3-Methylglutaconic acid can be used for brain damage disease research[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
References	[1]. Guilhian Leipnitz, et al. Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats. Life Sci. 2008 Mar 12;82(11-12):652-62. [2]. N L Alsip, et al. Cardiovascular effects of 3-mercaptopropionic acid and levels of GABA in regions of the brain of guinea-pigs. Neuropharmacology. 1984 Mar;23(3):349-57. [3]. E Girardi, et al. 3-mercaptopropionic acid-induced seizures decrease NR2B expression in Purkinje cells: cyclopentyladenosine effect. Cell Mol Neurobiol. 2010 Oct;30(7):985-90. [4]. Leipnitz G, et al. Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats. Life Sci. 2008 Mar 12;82(11-12):652-62.

Description

Related Catalog

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

References

[1]. Guilhian Leipnitz, et al. Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats. Life Sci. 2008 Mar 12;82(11-12):652-62.

[2]. N L Alsip, et al. Cardiovascular effects of 3-mercaptopropionic acid and levels of GABA in regions of the brain of guinea-pigs. Neuropharmacology. 1984 Mar;23(3):349-57.

[3]. E Girardi, et al. 3-mercaptopropionic acid-induced seizures decrease NR2B expression in Purkinje cells: cyclopentyladenosine effect. Cell Mol Neurobiol. 2010 Oct;30(7):985-90.

[4]. Leipnitz G, et al. Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats. Life Sci. 2008 Mar 12;82(11-12):652-62.

Density	1.307g/cm3
Boiling Point	399.4ºC at 760mmHg
Melting Point	101 - 105°C (lit.)
Molecular Formula	C₆H₈O₄
Molecular Weight	144.13
Flash Point	209.5ºC
Exact Mass	144.04200
PSA	74.60000
LogP	0.49200
Index of Refraction	1.508
InChIKey	WKRBKYFIJPGYQC-UHFFFAOYSA-N
SMILES	CC(=CC(=O)O)CC(=O)O
Storage condition	2-8°C

3-METHYLGLUTACONIC ACID MSDS(Chinese)

3-methyl-pentenedioic acid

3-METHYL-2-PENTENEDIOIC ACID

glutacouic acide 3-methyl

3-methylglutaric acid

3-Methylglutaconsaeure

3-METHYL-PENT-2-ENEDIOIC ACID

3-Methyl-pentendisaeure

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3-METHYLGLUTACONIC ACID

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3-METHYLGLUTACONIC ACID Biological Activity

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MSDS

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