4-Hydroxy-7-(trifluoromethyl)quinoline-3-carboxylic acid

Modify Date: 2023-01-17 12:33:36

4-Hydroxy-7-(trifluoromethyl)quinoline-3-carboxylic acid Structure
4-Hydroxy-7-(trifluoromethyl)quinoline-3-carboxylic acid structure
Common Name 4-Hydroxy-7-(trifluoromethyl)quinoline-3-carboxylic acid
CAS Number 574-92-5 Molecular Weight 257.16500
Density 1.55 g/cm3 Boiling Point 354.7ºC at 760 mmHg
Molecular Formula C11H6F3NO3 Melting Point 259-260 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 168.3ºC
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name 4-hydroxy-7-trifluoromethyl-3-quinolinecarboxylic acid
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.55 g/cm3
Boiling Point 354.7ºC at 760 mmHg
Melting Point 259-260 °C (dec.)(lit.)
Molecular Formula C11H6F3NO3
Molecular Weight 257.16500
Flash Point 168.3ºC
Exact Mass 257.03000
PSA 70.42000
LogP 2.65740

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VB2188000
CHEMICAL NAME :
3-Quinolinecarboxylic acid, 4-hydroxy-7-(trifluoromethyl)-
CAS REGISTRY NUMBER :
574-92-5
BEILSTEIN REFERENCE NO. :
0249406
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C11-H6-F3-N-O3
MOLECULAR WEIGHT :
257.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 9,585,1983

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS VB2188000

 Synthetic Route

~99%

4-Hydroxy-7-(trifluoromethyl)quinoline-3-carboxylic acid Structure

4-Hydroxy-7-(tr...

CAS#:574-92-5

Literature: Garudachari; Isloor, Arun M.; Satyanarayana; Fun, Hoong-Kun; Pavithra; Kulal, Ananda European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 422 - 432

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4-Hydroxy-7-(trifluoromethyl)quinoline-3-carboxylic acid Structure

4-Hydroxy-7-(tr...

CAS#:574-92-5

Literature: Journal of Medicinal Chemistry, , vol. 41, # 25 p. 4918 - 4926

~%

4-Hydroxy-7-(trifluoromethyl)quinoline-3-carboxylic acid Structure

4-Hydroxy-7-(tr...

CAS#:574-92-5

Literature: Journal of the American Chemical Society, , vol. 69, p. 371,373

 Articles1

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Synthesis and testing of new antileukemic Schiff bases of N-hydroxy-N'-aminoguanidine against CCRF-CEM/0 human leukemia cells in vitro and synergism studies with cytarabine (Ara-C).

Pharm. Res. 10(4) , 515-20, (1993)

A series of eight new N-hydroxy-N'-aminoguanidine (HAG) Schiff bases [ArCH = NNHC(= NH)NHOH.tosylate] was synthesized as potential antitumor agents through the inhibition of the enzyme ribonucleotide ...

 Synonyms

MFCD00006771
4-hydroxy-7-trifluoromethyl-3-quinoline-carboxylic acid
EINECS 209-377-8
4-Hydroxy-7-trifluoromethyl-3-quinolinecarboxylic acid,HPLC
4-HYDROXY-7-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ACID
4-hydroxy-7-(trifluoromethyl)-3-quinolinecarboxylicaci
4-Hydroxy-7-trifluormethyl-chinolin-3-carbonsaeure
3-Carboxy-4-hydroxy-7-trifluoromethylquinoline.
7-trifluoromethyl-4-hydroxyquinoline-3-carboxylic acid
BUTTPARK 219-48
4-HYDROXY-7-TRIFLUOROMETHYL-3-QUINOLINE-CARBOXYLIC ACID,TECH.
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