4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid

Modify Date: 2024-01-05 05:49:43

4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid structure	Common Name	4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid
	CAS Number	57078-98-5	Molecular Weight	183.161
	Density	1.4±0.1 g/cm3	Boiling Point	400.1±28.0 °C at 760 mmHg
	Molecular Formula	C₈H₉NO₄	Melting Point	95-98ºC
	MSDS	N/A	Flash Point	195.8±24.0 °C

Use of 4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid

4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	4-Maleimidobutyric Acid
Synonym	More Synonyms

Description	4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density	1.4±0.1 g/cm3
Boiling Point	400.1±28.0 °C at 760 mmHg
Melting Point	95-98ºC
Molecular Formula	C₈H₉NO₄
Molecular Weight	183.161
Flash Point	195.8±24.0 °C
Exact Mass	183.053162
PSA	74.68000
LogP	0.40
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.553
Storage condition	2-8°C

MSDS(Chinese)

Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36
WGK Germany	3

1H-Pyrrole-1-butanoic acid, 2,5-dihydro-2,5-dioxo-

4-(2,5-dioxopyrrol-1-yl)butanoic acid

4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoic acid

MFCD00043139

4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-butyric acid

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid
Price: ￥328.0/1g ￥1968.0/5g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

Chengdu Pukang Biotechnology Co., Ltd.
China
Product Name: 4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid
Price: ￥Inquiry/10g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Lihua Yang

DC Chemicals Limited
China
Product Name: 4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Maleimidobutyric acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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