57078-98-5

57078-98-5 structure

Name: 4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid
Chemical Name: 4-Maleimidobutyric Acid
CAS Number: 57078-98-5
Molecular Formula: C₈H₉NO₄
Molecular Weight: 183.161
Catalog: Chemical reagent Organic reagent Aromatic acid
Create Date: 2018-09-14 11:27:58
Modify Date: 2024-01-05 05:49:43
4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	4-Maleimidobutyric Acid
Synonyms	1H-Pyrrole-1-butanoic acid, 2,5-dihydro-2,5-dioxo- 4-(2,5-dioxopyrrol-1-yl)butanoic acid 4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoic acid MFCD00043139 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-butyric acid

Description	4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562