Minerval
Minerval structure
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Common Name | Minerval | ||
|---|---|---|---|---|
| CAS Number | 56472-29-8 | Molecular Weight | 298.46100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H34O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS05 |
Signal Word | Danger | |
Use of MinervalMinerval (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. Minerval has anti-tumor effect[1]. |
| Name | 2-Hydroxy Oleic Acid |
|---|---|
| Synonym | More Synonyms |
| Description | Minerval (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. Minerval has anti-tumor effect[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Minerval (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC50 of ~40 μM[1]. Minerval (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis[1]. Cell Viability Assay[1] Cell Line: Jurkat cells Concentration: 25 μM, 50 μM, 75 μM Incubation Time: 24 hours, 48 hours, 72 hours Result: Impaired Jurkat cell growth in a time- and concentration-dependent manner. Western Blot Analysis[1] Cell Line: Jurkat cells Concentration: 25 μM, 50 μM Incubation Time: 72 hours Result: Induced a marked and concentration-dependent increase in the proteolytic cleavage of PARP. |
| In Vivo | Minerval markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells[1]. Animal Model: 6-week-old nude male mice (Jurkat cells xenograft model)[1] Dosage: 600 mg/kg Administration: Oral administration; daily; for 21 days Result: Markedly and significantly inhibited tumour growth. |
| References |
| Molecular Formula | C18H34O3 |
|---|---|
| Molecular Weight | 298.46100 |
| Exact Mass | 298.25100 |
| PSA | 57.53000 |
| LogP | 5.07930 |
| Symbol |
GHS05 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H318 |
| Precautionary Statements | P280-P305 + P351 + P338 |
| Hazard Codes | C |
| Safety Phrases | 26-39 |
| RIDADR | NONH for all modes of transport |
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Minerval CAS#:56472-29-8 |
| Literature: Adam, Waldemar; Lazarus, Michael; Schmerder, Alexandra; Humpf, Hans-Ulrich; Saha-Moeller, Chantu R.; Schreier, Peter European Journal of Organic Chemistry, 1998 , # 9 p. 2013 - 2018 |
| Precursor 1 | |
|---|---|
| DownStream 1 | |
CAS#:7432-41-9|
2-Hydroxyoleic acid induces ER stress and autophagy in various human glioma cell lines.
PLoS ONE 7 , e48235, (2012) 2-Hydroxyoleic acid is a synthetic fatty acid with potent anti-cancer activity which does not induce undesired side effects. However, the molecular and cellular mechanisms by which this compound selec... |
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Sustained activation of sphingomyelin synthase by 2-hydroxyoleic acid induces sphingolipidosis in tumor cells.
J. Lipid Res. 54 , 1457-65, (2013) The mechanism of action of 2-hydroxyoleic acid (2OHOA), a potent antitumor drug, involves the rapid and specific activation of sphingomyelin synthase (SMS), leading to a 4-fold increase in SM mass in ... |
| (Z)-2-hydroxyoctadec-9-enoic acid |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Minerval
- Price: Check
- Purity: 98.0%
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- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Minerval
- Price: ￥1968.0/25mg ￥1158.0/5mg
- Purity: 98.0%
- Delivery: Inquiry
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- DC Chemicals Limited
- China
- Product Name: Minerval
- Price: $400.0/10mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Minerval
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 2-HYDROXYOLEICACID
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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