uperolein

Modify Date: 2024-09-23 09:29:55

uperolein Structure
uperolein structure
Common Name uperolein
CAS Number 55601-63-3 Molecular Weight 1234.380
Density 1.4±0.1 g/cm3 Boiling Point 1720.5±65.0 °C at 760 mmHg
Molecular Formula C57H79N13O16S Melting Point N/A
MSDS N/A Flash Point 994.3±34.3 °C

 Use of uperolein


Uperolein is a physalaemin-like endecapeptide, produced in the skin of Uperoleia rugosa and Uperoleia marmorata. Uperolein has a spasmodic effect on both the gastrointestinal tract and longitudinal muscles[1][2][3].

 Names

Name 5-Oxoprolylprolyl-α-aspartylprolylasparaginylalanylphenylalanyltyrosylglycylleucylmethioninamide
Synonym More Synonyms

 uperolein Biological Activity

Description Uperolein is a physalaemin-like endecapeptide, produced in the skin of Uperoleia rugosa and Uperoleia marmorata. Uperolein has a spasmodic effect on both the gastrointestinal tract and longitudinal muscles[1][2][3].
Related Catalog
In Vitro Uperolein (10-100 ng/mL) is a tachykinin analogue, causes or reinforces rhythmic movements and increases the tone in isolated circular and longitudinal muscle of the human gastrointestinal tract from the stomach to the colon[2].
In Vivo Uperolein (0.1 μg/kg and 5 μg/kg; i.v.; single dose) exhibits stimulation activity on the stomach of the anesthetized rat, displays a noticeable spasmogenic activity on the whole stomach from the fundus to the pylorus[3].
References

[1]. Poulter L, et al. Levitide, a neurohormone-like peptide from the skin of Xenopus laevis. Peptide and peptide precursor cDNA sequences. J Biol Chem. 1988 Mar 5;263(7):3279-83.  

[2]. Anastasi A, et al. Structure of uperolein, a physalaemin-like endecapeptide occurring in the skin of Uperoleia rugosa and Uperoleia marmorata. Experientia. 1975 Apr 15;31(4):394-5.  

[3]. Zappia L, et al. Effects of natural analogues of substance P on the motility of human gastrointestinal tract in vitro. J Pharm Pharmacol. 1978 Sep;30(9):593-4.  

[4]. Bertaccini G, et al. Action of some natural peptides on the stomach of the anaesthetized rat. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):163-6.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 1720.5±65.0 °C at 760 mmHg
Molecular Formula C57H79N13O16S
Molecular Weight 1234.380
Flash Point 994.3±34.3 °C
Exact Mass 1233.548828
LogP -0.10
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.600

 Synonyms

Methioninamide, 5-oxoprolylprolyl-α-aspartylprolylasparaginylalanylphenylalanyltyrosylglycylleucyl-
5-Oxoprolylprolyl-α-aspartylprolylasparaginylalanylphenylalanyltyrosylglycylleucylmethioninamide
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