uperolein

Names

[ Name ]:
uperolein

[Synonym ]:
Methioninamide, 5-oxoprolylprolyl-α-aspartylprolylasparaginylalanylphenylalanyltyrosylglycylleucyl-
5-Oxoprolylprolyl-α-aspartylprolylasparaginylalanylphenylalanyltyrosylglycylleucylmethioninamide

Biological Activity

[Description]:

Uperolein is a physalaemin-like endecapeptide, produced in the skin of Uperoleia rugosa and Uperoleia marmorata. Uperolein has a spasmodic effect on both the gastrointestinal tract and longitudinal muscles[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

Uperolein (10-100 ng/mL) is a tachykinin analogue, causes or reinforces rhythmic movements and increases the tone in isolated circular and longitudinal muscle of the human gastrointestinal tract from the stomach to the colon[2].

[In Vivo]

Uperolein (0.1 μg/kg and 5 μg/kg; i.v.; single dose) exhibits stimulation activity on the stomach of the anesthetized rat, displays a noticeable spasmogenic activity on the whole stomach from the fundus to the pylorus[3].

[References]

[1]. Poulter L, et al. Levitide, a neurohormone-like peptide from the skin of Xenopus laevis. Peptide and peptide precursor cDNA sequences. J Biol Chem. 1988 Mar 5;263(7):3279-83.

[2]. Anastasi A, et al. Structure of uperolein, a physalaemin-like endecapeptide occurring in the skin of Uperoleia rugosa and Uperoleia marmorata. Experientia. 1975 Apr 15;31(4):394-5.

[3]. Zappia L, et al. Effects of natural analogues of substance P on the motility of human gastrointestinal tract in vitro. J Pharm Pharmacol. 1978 Sep;30(9):593-4.

[4]. Bertaccini G, et al. Action of some natural peptides on the stomach of the anaesthetized rat. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):163-6.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1720.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₅₇H₇₉N₁₃O₁₆S

[ Molecular Weight ]:
1234.380

[ Flash Point ]:
994.3±34.3 °C

[ Exact Mass ]:
1233.548828

[ LogP ]:
-0.10

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.600

Related Compounds

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