Triclopyr

Modify Date: 2024-01-02 09:31:26

Triclopyr structure	Common Name	Triclopyr
	CAS Number	55335-06-3	Molecular Weight	256.471
	Density	1.7±0.1 g/cm3	Boiling Point	359.1±37.0 °C at 760 mmHg
	Molecular Formula	C₇H₄Cl₃NO₃	Melting Point	148-150°C
	MSDS	Chinese USA	Flash Point	171.0±26.5 °C
	Symbol	GHS07	Signal Word	Warning

Use of Triclopyr

Triclopyr, a foliar systemic herbicide and fungicide, is widely used for broadleaf and woody plant control. Triclopyr has severe toxicity[1].

Name	trichlopyr
Synonym	More Synonyms

Description	Triclopyr, a foliar systemic herbicide and fungicide, is widely used for broadleaf and woody plant control. Triclopyr has severe toxicity[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Triclopyr (3 mM; 48 hours) treatment exhibits cytotoxicity against N2a cells[1]. Cell Cytotoxicity Assay[1] Cell Line: Mouse neuroblastoma (N2a) cells Concentration: 3 mM Incubation Time: 48 hours Result: Decreased significantly for cell viability (P < 0.0001) compared to the untreated N2a cells.
In Vivo	Pharmacokinetic Analysis Triclopyr exhibits moderate half-lives (dog 25 h and monkey 6.3 h) due to plasma clearance (18 mL/h/kg, 26 mL/h/kg respectively) following oral gavage (3 male beagle dogs ;0.5 mg/kg, 5 mg/kg and 20 mg/kg) and intravenous administration (1 male rhesus monkey; 30 mg/kg) [2]. Animal Model: 3 male beagle dogs(7.2 - 7.9 kg), 1 male rhesus monkey [2] Dosage: 0.5 mg/kg, 5 mg/kg, 20 mg/kg (beagle dog); 30 mg/kg (rhesus monkey) Administration: Oral gavage (beagle dog); intravenous (rhesus monkey) Result: T1/2s of 25 and 6.3 h for dogs and a monkey, respectively.
References	[1]. Tejaswini P Reddy, et al. Toxicity of neurons treated with herbicides and neuroprotection by mitochondria-targeted antioxidant SS31. Int J Environ Res Public Health. 2011 Jan;8(1):203-21. [2]. C Timchalk, et al. Pharmacokinetics of triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) in the beagle dog and rhesus monkey: perspective on the reduced capacity of dogs to excrete this organic acid relative to the rat, monkey, and human. Toxicol Appl Pharmacol. 1997 Jun;144(2):268-78.

Density	1.7±0.1 g/cm3
Boiling Point	359.1±37.0 °C at 760 mmHg
Melting Point	148-150°C
Molecular Formula	C₇H₄Cl₃NO₃
Molecular Weight	256.471
Flash Point	171.0±26.5 °C
Exact Mass	254.925674
PSA	59.42000
LogP	2.98
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.591

Triclopyr MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AJ9000000

CHEMICAL NAME :: Acetic acid, (3,5,6-trichloro-2-pyridyloxy)-

CAS REGISTRY NUMBER :: 55335-06-3

BEILSTEIN REFERENCE NO. :: 0225301

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C7-H4-Cl3-N-O3

MOLECULAR WEIGHT :: 256.47

WISWESSER LINE NOTATION :: T6NJ BO1VQ CG EG FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 630 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C310,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 550 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,844,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,844,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 310 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,844,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 1693 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945- Volume(issue)/page/year: 35,25,1979 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1820 mg/kg/13W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,1,1985 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1550 mg/kg

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,872,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,872,1984 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
RTECS	AJ9000000
HS Code	3808931100

Acetic acid, (3...

CAS#:60825-27-6

~91%

Triclopyr

CAS#:55335-06-3

Literature: EXCEL CROP CARE LIMITED; C C SHROFF RESEARCH INSTITUTE; AIMCO PESTICIDES LIMITED; SHROFF, Dipesh, Kantisen; SHROFF, Ashwin, Champraj; DAVE, Samir, Pradip Patent: WO2010/23679 A2, 2010 ; Location in patent: Page/Page column 9; 10 ;

(3|A,4abeta,12a...

CAS#:60825-26-5

~95%

Triclopyr

CAS#:55335-06-3

EDA

CAS#:623-73-4

3,5,6-Trichloro...

CAS#:6515-38-4

Triclopyr

CAS#:55335-06-3

Literature: Journal of Organic Chemistry, , vol. 23, p. 1614

Precursor 4
CAS#:60825-27-6 Acetic acid, (3... CAS#:60825-26-5 (3\|A,4abeta,12a... CAS#:623-73-4 EDA CAS#:6515-38-4 3,5,6-Trichloro...
DownStream 0

HS Code	2933399028
Summary	2933399028 2-((3,5,6-trichloropyridin-2-yl)oxy)acetic acid。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

Are DNA-damaging effects induced by herbicide formulations (Roundup® and Garlon®) in fish transient and reversible upon cessation of exposure?

Aquat. Toxicol. 155 , 213-21, (2014)

Owing to the seasonality of crop cultivation and subsequent periodic/seasonal application of herbicides, their input to the aquatic systems is typically intermittent. Consequently, exposure of fish to...

Dissipation of four forest-use herbicides at high latitudes.

Environ. Sci. Pollut. Res. Int. 15(7) , 573-83, (2008)

Large-scale deforestation is occurring in subarctic North America following clearing by salvage logging or insect attack. Numerous shrubs, herbs, and deciduous tree species tend to dominate areas on w...

Effects of herbicides on Behr's metalmark butterfly, a surrogate species for the endangered butterfly, Lange's metalmark.

Environ. Pollut. 164 , 24-7, (2012)

Lange's metalmark butterfly, Apodemia mormo langei Comstock, is in danger of extinction due to loss of habitat caused by invasive exotic plants which are eliminating its food, naked stem buckwheat. He...

Acetic acid, 2-[(3,5,6-trichloro-2-pyridinyl)oxy]-

Acetic acid, [(3,5,6-trichloro-2-pyridinyl)oxy]-

Rely

Garlon

Caswell No. 882I

Timbrel

[(3,5,6-Trichloro-2-pyridinyl)oxy]acetic acid

EINECS 259-597-3

Exetor

Mutan

3,5,6-trichloro-2-pyridyloxyacetic acid

Remedy

TRIDENT

MFCD00072514

Triclopyr

3,5,6-trichloropyrid-2-yloxyacetic acid

2-[(3,5,6-trichloro-2-pyridinyl)oxy]acetic acid

T6NJ BO1VQ CG EG FG

3,5,6-trichloro-pyridin-2-yl-oxyacetic acid

Curtail

Redeem

M 3724

[(3,5,6-Trichloropyridin-2-yl)oxy]acetic acid

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Triclopyr
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China
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DC Chemicals Limited
China
Product Name: Triclopyr
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Triclopyr
Price: ￥Inquiry/1g
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Dayang Chem (Hangzhou) Co., Ltd.
China
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Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: trichlopyr
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Triclopyr

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