IHR 1
Modify Date: 2025-08-29 21:33:09
IHR 1 structure
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Common Name | IHR 1 | ||
|---|---|---|---|---|
| CAS Number | 548779-60-8 | Molecular Weight | 454.134 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 488.4±45.0 °C at 760 mmHg | |
| Molecular Formula | C20H12Cl4N2O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 249.2±28.7 °C | |
Use of IHR 1A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay; blocks Smo accumulation in the primary cilium without inhibiting SAG-induced pathway response. |
| Name | IHR-1 |
|---|---|
| Synonym | More Synonyms |
| Description | A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay; blocks Smo accumulation in the primary cilium without inhibiting SAG-induced pathway response. |
|---|---|
| References | References 1. Fan CW, et al. Chem Biol. 2014 Dec 18;21(12):1680-9. View Related Products by Target Smoothened (Smo) |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 488.4±45.0 °C at 760 mmHg |
| Molecular Formula | C20H12Cl4N2O2 |
| Molecular Weight | 454.134 |
| Flash Point | 249.2±28.7 °C |
| Exact Mass | 451.965302 |
| LogP | 5.01 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.708 |
| InChIKey | VCLHHRGZKNUOAQ-UHFFFAOYSA-N |
| SMILES | O=C(Nc1ccc(NC(=O)c2cc(Cl)ccc2Cl)cc1)c1cc(Cl)ccc1Cl |
| Storage condition | 2-8°C |
| Hazard Statements | H413 |
|---|---|
| RIDADR | NONH for all modes of transport |
| IHR-1 |
| N,N'-1,4-Phenylenebis(2,5-dichlorobenzamide) |
| MFCD03404776 |
| Benzamide, N,N'-1,4-phenylenebis[2,5-dichloro- |
| N,N'-1,4-Phenylenebis[2,5-dichloro-benzamide] |