548779-60-8
548779-60-8 structure
- Name: IHR 1
- Chemical Name: IHR-1
- CAS Number: 548779-60-8
- Molecular Formula: C20H12Cl4N2O2
- Molecular Weight: 454.134
- Catalog: Signaling Pathways Stem Cell/Wnt Smo
- Create Date: 2020-01-11 14:15:32
- Modify Date: 2025-08-29 21:33:09
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A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay; blocks Smo accumulation in the primary cilium without inhibiting SAG-induced pathway response.
| Name | IHR-1 |
|---|---|
| Synonyms |
IHR-1
N,N'-1,4-Phenylenebis(2,5-dichlorobenzamide) MFCD03404776 Benzamide, N,N'-1,4-phenylenebis[2,5-dichloro- N,N'-1,4-Phenylenebis[2,5-dichloro-benzamide] |
| Description | A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay; blocks Smo accumulation in the primary cilium without inhibiting SAG-induced pathway response. |
|---|---|
| References | References 1. Fan CW, et al. Chem Biol. 2014 Dec 18;21(12):1680-9. View Related Products by Target Smoothened (Smo) |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 488.4±45.0 °C at 760 mmHg |
| Molecular Formula | C20H12Cl4N2O2 |
| Molecular Weight | 454.134 |
| Flash Point | 249.2±28.7 °C |
| Exact Mass | 451.965302 |
| LogP | 5.01 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.708 |
| Storage condition | 2-8°C |
| Hazard Statements | H413 |
|---|---|
| RIDADR | NONH for all modes of transport |