Irigenin

Modify Date: 2024-01-02 13:05:44

Irigenin structure	Common Name	Irigenin
	CAS Number	548-76-5	Molecular Weight	360.31500
	Density	1.461g/cm3	Boiling Point	646.1ºC at 760mmHg
	Molecular Formula	C₁₈H₁₆O₈	Melting Point	189-192ºC
	MSDS	N/A	Flash Point	237.7ºC

Use of Irigenin

Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells[1].

Name	irigenin
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Description	Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cytoskeleton >> Integrin
In Vitro	Irigenin specifically targets α9β1 and α4β1 integrin binding sites on Extra Domain A (EDA) comprising LEU46, PHE47, PRO48, GLU58, LEU59 and GLN60 in its C-C loop. Irigenin binds to the C-C loop of EDA, thereby blocking its interaction with integrins on the cell surface and thus abrogating subsequent Epithelial-Mesenchymal transition[1].
References	[1]. Amin A, et al. Irigenin, a novel lead from Western Himalayan chemiome inhibits Fibronectin-Extra Domain A induced metastasis in Lung cancer cells. Sci Rep. 2016 Nov 16;6:37151. [2]. Xu Y, et al. Irigenin sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells. Biochem Biophys Res Commun. 2018 Feb 12;496(3):998-1005.

Density	1.461g/cm3
Boiling Point	646.1ºC at 760mmHg
Melting Point	189-192ºC
Molecular Formula	C₁₈H₁₆O₈
Molecular Weight	360.31500
Flash Point	237.7ºC
Exact Mass	360.08500
PSA	118.59000
LogP	2.60260
Index of Refraction	1.649
Storage condition	2-8C

HS Code	2914509090

Precursor 0
DownStream 2
CAS#:64-18-6 Formic Acid CAS#:487-71-8 Iretol

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxychromen-4-one

7,5,3'-Trihydroxy-6,4',5'-trimethoxyisoflavon

5,7,3'-trihydroxy-6,4',5'-trimethoxyisoflavone

Irigenin

EINECS 208-958-3

BioBioPha
China
Product Name: Irigenin
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Irigenin
Price: ￥968.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Irigenin
Price: $600.0/100mg $1100.0/250mg $2000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥800/5 mg

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Irigenin

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