4-methoxy-1,3-benzothiazol-2-amine

Modify Date: 2024-01-09 17:17:28

4-methoxy-1,3-benzothiazol-2-amine Structure
4-methoxy-1,3-benzothiazol-2-amine structure
Common Name 4-methoxy-1,3-benzothiazol-2-amine
CAS Number 5464-79-9 Molecular Weight 180.227
Density 1.4±0.1 g/cm3 Boiling Point 347.5±34.0 °C at 760 mmHg
Molecular Formula C8H8N2OS Melting Point 153-155 °C(lit.)
MSDS USA Flash Point 163.9±25.7 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name 2-Amino-4-methoxybenzothiazole
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 347.5±34.0 °C at 760 mmHg
Melting Point 153-155 °C(lit.)
Molecular Formula C8H8N2OS
Molecular Weight 180.227
Flash Point 163.9±25.7 °C
Exact Mass 180.035736
PSA 76.38000
LogP 1.81
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.705
Water Solubility <0.1 g/100 mL at 19.5 ºC

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DL2000000
CHEMICAL NAME :
Benzothiazole, 2-amino-4-methoxy-
CAS REGISTRY NUMBER :
5464-79-9
BEILSTEIN REFERENCE NO. :
0141363
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C8-H8-N2-O-S
MOLECULAR WEIGHT :
180.24
WISWESSER LINE NOTATION :
T56 BN DSJ CZ IO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
562 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
46 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
10 ug/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 39,682,1979

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302 + H312 + H332
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R20/21/22
Safety Phrases S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS DL2000000
HS Code 2934999090

 Synthetic Route

~70%

4-methoxy-1,3-benzothiazol-2-amine Structure

4-methoxy-1,3-b...

CAS#:5464-79-9

Literature: Sharma, Pratibha; Kumar, Ashok; Kumari, Prerna; Singh, Jitendra; Kaushik Medicinal Chemistry Research, 2012 , vol. 21, # 7 p. 1136 - 1148

~92%

4-methoxy-1,3-benzothiazol-2-amine Structure

4-methoxy-1,3-b...

CAS#:5464-79-9

Literature: Telvekar, Vikas N.; Bachhav, Harshal M.; Bairwa, Vinod Kumar Synlett, 2012 , vol. 23, # 15 p. 2219 - 2222

~67%

4-methoxy-1,3-benzothiazol-2-amine Structure

4-methoxy-1,3-b...

CAS#:5464-79-9

Literature: Patel, Navin B.; Agravat, Suresh N.; Shaikh, Faiyazalam M. Medicinal Chemistry Research, 2011 , vol. 20, # 7 p. 1033 - 1041

~%

4-methoxy-1,3-benzothiazol-2-amine Structure

4-methoxy-1,3-b...

CAS#:5464-79-9

Literature: Medicinal Chemistry Research, , vol. 21, # 7 p. 1136 - 1148

~%

4-methoxy-1,3-benzothiazol-2-amine Structure

4-methoxy-1,3-b...

CAS#:5464-79-9

Literature: Helvetica Chimica Acta, , vol. 25, p. 515,519 Yakugaku Zasshi, , vol. 60, p. 462,473; dtsch. Ref. S. 184, 189 Chem.Abstr., , p. 452

~%

4-methoxy-1,3-benzothiazol-2-amine Structure

4-methoxy-1,3-b...

CAS#:5464-79-9

Literature: Heterocycles, , vol. 14, # 8 p. 1145 - 1149

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles2

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Antibacterial Zn (II) compounds of. Schiff bases derived from some benzothiazoles. Chohan ZH and Supuran CT.

Main Group Met. Chem. 25(5) , 291-296, (2002)

Synthesis of Some New 2-(4-Methoxybenzothiazol-2'-yl amino)-4-(2-chloro-4-trifluoromethylanilino)-6-(substituted thioureido)-1, 3, 5-triazine as Antifungal Agents. Sareen V, et al.

Phosph. Sulfur Relat. Elem. 185(1) , 140-146, (2009)

 Synonyms

EINECS 226-763-1
MFCD00005792
4-methoxy-1,3-benzothiazol-2-amine
2-Benzothiazolamine, 4-methoxy-