R-Tetrahydropapaverine

Modify Date: 2025-08-26 22:16:54

R-Tetrahydropapaverine Structure
R-Tetrahydropapaverine structure
Common Name R-Tetrahydropapaverine
CAS Number 54417-53-7 Molecular Weight 379.88
Density 1.12 g/cm3 Boiling Point 475.8ºC at 760 mmHg
Molecular Formula C20H26ClNO4 Melting Point N/A
MSDS N/A Flash Point 202.7ºC

 Use of R-Tetrahydropapaverine


(R)-Tetrahydropapaverine hydrochloride is the inactive isomer of Tetrahydropapaverine hydrochloride (HY-N0137), and can be used as an experimental control. Tetrahydropapaverine hydrochloride is one of the Tetrahydroisoquinolines. Tetrahydropapaverine hydrochloride has neurotoxic effects on dopamine neurons[1][2].

 Names

Name R-Tetrahydropapaverine
Synonym More Synonyms

 R-Tetrahydropapaverine Biological Activity

Description (R)-Tetrahydropapaverine hydrochloride is the inactive isomer of Tetrahydropapaverine hydrochloride (HY-N0137), and can be used as an experimental control. Tetrahydropapaverine hydrochloride is one of the Tetrahydroisoquinolines. Tetrahydropapaverine hydrochloride has neurotoxic effects on dopamine neurons[1][2].
Related Catalog
References

[1]. Koshimura I, et al. Dimethoxyphenylethylamine and tetrahydropapaverine are toxic to the nigrostriatal system. Brain Res. 1997 Oct 31;773(1-2):108-16.  

[2]. Kim EI, et al. Inhibitory effects of tetrahydropapaverine on serotonin biosynthesis in murine mastocytoma P815 cells. Life Sci. 2004 Sep 3;75(16):1949-57.  

 Chemical & Physical Properties

Density 1.12 g/cm3
Boiling Point 475.8ºC at 760 mmHg
Molecular Formula C20H26ClNO4
Molecular Weight 379.88
Flash Point 202.7ºC
Exact Mass 379.155029
PSA 48.95000
LogP 4.28130
Index of Refraction 1.549
InChIKey VMPLLPIDRGXFTQ-PKLMIRHRSA-N
SMILES COc1ccc(CC2NCCc3cc(OC)c(OC)cc32)cc1OC.Cl

 Safety Information

Hazard Codes Xn:Harmful;
Risk Phrases R22;R52/53
Safety Phrases S22-S61
HS Code 2933499090

 Synthetic Route

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R-Tetrahydropapaverine Structure

R-Tetrahydropap...

CAS#:54417-53-7

Literature: WO2009/106547 A1, ; Page/Page column 9-10 ;

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R-Tetrahydropapaverine Structure

R-Tetrahydropap...

CAS#:54417-53-7

Literature: Tetrahedron Letters, , vol. 22, # 39 p. 3869 - 3872

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

(R)-(-)-Norlaudanosine Hydrochloride
(R)-1-((3,4-dimethoxyphenyyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline hydrochloride
MFCD03788189
(R)-Tetrahydropapaverinehydrochloride
EINECS 415-110-8
R-(+)-TETRAHYDROPAPAVERIN HYDROCHLORIDE
http://www.gabrielpharm.com/hy/detailpro.phpid=39
(R)-1,2,3,4-tetrahydropapaverine hydrochloride
(R)-tetrahydropaverine hydrochloride
Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, hydrochloride (1:1)
(R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratrylisoquinoline hydrochloride
D-(-)-Norlaudanosine hydrochloride
(R)-1-(3,4-DIMETHOXY-BENZYL)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HCL
R-BINAP
1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (1:1)
R-(+)-Tetrahydropapaverin
(r)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratrylisoquinoline
R-(-)-norlaudanosine*HCl
R-tetrahydropapaverine HCl
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