ADRENOCHROME

Modify Date: 2024-01-03 12:25:27

ADRENOCHROME Structure
ADRENOCHROME structure
Common Name ADRENOCHROME
CAS Number 54-06-8 Molecular Weight 179.17300
Density 1.42g/cm3 Boiling Point 375.1ºC at 760 mmHg
Molecular Formula C9H9NO3 Melting Point 115-120ºC
MSDS Chinese USA Flash Point 180.7ºC

 Use of ADRENOCHROME


Adrenochrome (Adraxone) is an oxidation product of Epinephrine. Adrenochrome is a potent coronary constricting agent in the rat heart. Adrenochrome can be used for neurological disorder research[1][2][3].

 Names

Name 3-Hydroxy-1-methyl-5,6-indolinedione
Synonym More Synonyms

 ADRENOCHROME Biological Activity

Description Adrenochrome (Adraxone) is an oxidation product of Epinephrine. Adrenochrome is a potent coronary constricting agent in the rat heart. Adrenochrome can be used for neurological disorder research[1][2][3].
Related Catalog
In Vitro Adrenochrome decreases microsomal calcium binding, calcium uptake and Ca2+-stimulated Mg2+-dependent ATPase activities. The inhibitory effect of Adrenochrome on microsomal calcium uptake activity of the isolated membrane is independent of pH (6.0-8.0), calcium concentrations (10-200 μM), protein concentration (0.02-0.10 mg/mL), temperature (25-37 degrees C) and incubation time (2-30 min)[2].
In Vivo In isolated rat hearts, concentrations of Adrenochrome from 1 to 1000 ng/mL increases coronary pressure in a dose- and time-dependent manner. Furthermore, the degree of constriction by Adrenochrome is dependent on the CaCl2 concentration in the perfusion medium[1].
References

[1]. M Karmazyn,, et al. Adrenochrome-induced coronary artery constriction in the rat heart. J Pharmacol Exp Ther. 1981 Oct;219(1):225-30.

[2]. S Takeo,et al. Effects of adrenochrome on calcium accumulating and adenosine triphosphatase activities of the rat heart microsomes. J Pharmacol Exp Ther. 1980 Sep;214(3):688-93.

[3]. Koji Ueda, et al. Catecholamine oxidation-mediated transcriptional inhibition in Mn neurotoxicity. J Toxicol Sci. 2020;45(10):619-624.

 Chemical & Physical Properties

Density 1.42g/cm3
Boiling Point 375.1ºC at 760 mmHg
Melting Point 115-120ºC
Molecular Formula C9H9NO3
Molecular Weight 179.17300
Flash Point 180.7ºC
Exact Mass 179.05800
PSA 57.61000
Index of Refraction 1.63

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NM1925000
CHEMICAL NAME :
5,6-Indolinedione, 3-hydroxy-1-methyl-
CAS REGISTRY NUMBER :
54-06-8
LAST UPDATED :
199206
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C9-H9-N-O3
MOLECULAR WEIGHT :
179.19
WISWESSER LINE NOTATION :
T56 BN GVVT&J B1 DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 106,90,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
128 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 106,90,1956

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases 36/37/38
RIDADR NONH for all modes of transport
RTECS NM1925000
HS Code 2933990090

 Synthetic Route

~%

ADRENOCHROME Structure

ADRENOCHROME

CAS#:54-06-8

Literature: Kytzia, Anna; Korth, Hans-Gert; De Groot, Herbert; Kirsch, Michael Organic and Biomolecular Chemistry, 2006 , vol. 4, # 2 p. 257 - 267

~%

ADRENOCHROME Structure

ADRENOCHROME

CAS#:54-06-8

Literature: Pispisa, Basilio; Palleschi, Antonio; Paradossi, Gaio; Chiavarini, Salvatore Gazzetta Chimica Italiana, 1986 , vol. 116, # 8 p. 423 - 430

~%

ADRENOCHROME Structure

ADRENOCHROME

CAS#:54-06-8

Literature: Kruk, I. Zeitschrift fuer Physikalische Chemie (Leipzig), 1987 , vol. 268, # 3 p. 607 - 613

~%

ADRENOCHROME Structure

ADRENOCHROME

CAS#:54-06-8

Literature: Skully, Joan P.; McCreery, Richard L. Analytical Chemistry, 1980 , vol. 52, # 12 p. 1885 - 1889

~%

ADRENOCHROME Structure

ADRENOCHROME

CAS#:54-06-8

Literature: Skully, Joan P.; McCreery, Richard L. Analytical Chemistry, 1980 , vol. 52, # 12 p. 1885 - 1889

 Precursor & DownStream

Precursor  3

DownStream  0

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

adrenochrome
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