8-Prenylnaringenin

Modify Date: 2024-01-02 19:27:03

8-Prenylnaringenin structure	Common Name	8-Prenylnaringenin
	CAS Number	53846-50-7	Molecular Weight	340.370
	Density	1.3±0.1 g/cm3	Boiling Point	597.6±50.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₀O₅	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	216.4±23.6 °C

Use of 8-Prenylnaringenin

8-prenylnaringenin is a prenylflavonoid isolated from hop cones (Humulus lupulus), with cytotoxicity. 8-prenylnaringenin has anti-proliferative activity against HCT-116 colon cancer cells via induction of intrinsic and extrinsic pathway-mediated apoptosis. 8-Prenylnaringenin also promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice[1] [2] [3].

Name	8-Prenylnaringenin
Synonym	More Synonyms

Description	8-prenylnaringenin is a prenylflavonoid isolated from hop cones (Humulus lupulus), with cytotoxicity. 8-prenylnaringenin has anti-proliferative activity against HCT-116 colon cancer cells via induction of intrinsic and extrinsic pathway-mediated apoptosis. 8-Prenylnaringenin also promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice[1] [2] [3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Koosha S, et al. Antiproliferative and apoptotic activities of 8-prenylnaringenin against human colon cancer cells. Life Sci. 2019 Jul 3:116633. [2]. Mukai R, et al. 8-Prenylnaringenin promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice. Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1022-R1031. [3]. Stompor M, et al. In Vitro Effect of 8-Prenylnaringenin and Naringenin on Fibroblasts and Glioblastoma Cells-Cellular Accumulation and Cytotoxicity. Molecules. 2017 Jun 30;22(7).

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

References

[1]. Koosha S, et al. Antiproliferative and apoptotic activities of 8-prenylnaringenin against human colon cancer cells. Life Sci. 2019 Jul 3:116633.

[2]. Mukai R, et al. 8-Prenylnaringenin promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice. Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1022-R1031.

[3]. Stompor M, et al. In Vitro Effect of 8-Prenylnaringenin and Naringenin on Fibroblasts and Glioblastoma Cells-Cellular Accumulation and Cytotoxicity. Molecules. 2017 Jun 30;22(7).

Density	1.3±0.1 g/cm3
Boiling Point	597.6±50.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₀O₅
Molecular Weight	340.370
Flash Point	216.4±23.6 °C
Exact Mass	340.131073
PSA	86.99000
LogP	5.28
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.642
Storage condition	2-8°C

Hazard Codes	Xi
RIDADR	NONH for all modes of transport

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8-Prenylnaringenin

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