UF010
Modify Date: 2024-01-29 09:44:33
UF010 structure
|
Common Name | UF010 | ||
|---|---|---|---|---|
| CAS Number | 537672-41-6 | Molecular Weight | 271.154 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 326.7±34.0 °C at 760 mmHg | |
| Molecular Formula | C11H15BrN2O | Melting Point | N/A | |
| MSDS | USA | Flash Point | 151.4±25.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of UF010UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs.IC50 value: 0.06 μM (HDAC3), 0.1 μM (HDAC2), 0.5 μM (HDAC1), 1.5 μM(HDAC 8)Target: HDACin vitro: UF010 is a competitive inhibitor with a fast-on/slow-off HDAC-binding mechanism. UF010 induces accumulation of acetylated histones in HCT116 cells in vitro, arrests cells at G1/S transition. It inhibits proliferation of a range of cancer cell lines. UF010 activates tumor suppression mechanisms while inhibiting oncogenic pathways. |
| Name | 4-Bromo-N'-butylbenzohydrazide |
|---|---|
| Synonym | More Synonyms |
| Description | UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs.IC50 value: 0.06 μM (HDAC3), 0.1 μM (HDAC2), 0.5 μM (HDAC1), 1.5 μM(HDAC 8)Target: HDACin vitro: UF010 is a competitive inhibitor with a fast-on/slow-off HDAC-binding mechanism. UF010 induces accumulation of acetylated histones in HCT116 cells in vitro, arrests cells at G1/S transition. It inhibits proliferation of a range of cancer cell lines. UF010 activates tumor suppression mechanisms while inhibiting oncogenic pathways. |
|---|---|
| Related Catalog | |
| Target |
HDAC3:0.06 μM (IC50) HDAC2:0.1 μM (IC50) HDAC1:0.5 μM (IC50) HDAC8:1.5 μM (IC50) HDAC6:9.1 μM (IC50) HDAC10:15.3 μM (IC50) HDAC11:44.5 μM (IC50) |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 326.7±34.0 °C at 760 mmHg |
| Molecular Formula | C11H15BrN2O |
| Molecular Weight | 271.154 |
| Flash Point | 151.4±25.7 °C |
| Exact Mass | 270.036774 |
| LogP | 3.46 |
| Appearance of Characters | white solid |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.550 |
| Storage condition | -20℃ |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| RIDADR | NONH for all modes of transport |
| 4-Bromo-N'-butylbenzohydrazide |
| Benzoic acid, 4-bromo-, 2-butylhydrazide |
| UF010 |