UF010

Names

[ Name ]:
UF010

[Synonym ]:
4-Bromo-N'-butylbenzohydrazide
Benzoic acid, 4-bromo-, 2-butylhydrazide
UF010

Biological Activity

[Description]:

UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs.IC50 value: 0.06 μM (HDAC3), 0.1 μM (HDAC2), 0.5 μM (HDAC1), 1.5 μM(HDAC 8)Target: HDACin vitro: UF010 is a competitive inhibitor with a fast-on/slow-off HDAC-binding mechanism. UF010 induces accumulation of acetylated histones in HCT116 cells in vitro, arrests cells at G1/S transition. It inhibits proliferation of a range of cancer cell lines. UF010 activates tumor suppression mechanisms while inhibiting oncogenic pathways.

[Related Catalog]:

Research Areas >> Cancer

[Target]

HDAC3:0.06 μM (IC50)

HDAC2:0.1 μM (IC50)

HDAC1:0.5 μM (IC50)

HDAC8:1.5 μM (IC50)

HDAC6:9.1 μM (IC50)

HDAC10:15.3 μM (IC50)

HDAC11:44.5 μM (IC50)

[References]

[1]. Wang Y, et al. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chem Biol. 2015 Feb 19;22(2):273-284.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
326.7±34.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₅BrN₂O

[ Molecular Weight ]:
271.154

[ Flash Point ]:
151.4±25.7 °C

[ Exact Mass ]:
270.036774

[ LogP ]:
3.46

[ Appearance of Characters ]:
white solid

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.550

[ Storage condition ]:
-20℃

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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