Euscaphic acid

Modify Date: 2024-01-02 16:37:51

Euscaphic acid structure	Common Name	Euscaphic acid
	CAS Number	53155-25-2	Molecular Weight	488.699
	Density	1.2±0.1 g/cm3	Boiling Point	602.7±55.0 °C at 760 mmHg
	Molecular Formula	C₃₀H₄₈O₅	Melting Point	262-264℃
	MSDS	N/A	Flash Point	332.3±28.0 °C

Use of Euscaphic acid

Euscaphic acid, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC50 values of 61 and 108 μM[1]. Euscaphic acid induces apoptosis[2].

Name	euscaphic acid
Synonym	More Synonyms

Description	Euscaphic acid, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC50 values of 61 and 108 μM[1]. Euscaphic acid induces apoptosis[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	IC50: 61 μM (calf DNA polymerase α); 108 μM (rat DNA polymerase β)[1]; apoptosis[2]
In Vitro	Euscaphic acid induces apoptosis and cell cycle arrest in NPC cells by suppression of the PI3K/AKT/mTOR signaling pathway[2].
References	[1]. Murakami C, et al. Novel anti-inflammatory compounds from Rubus sieboldii, triterpenoids, are inhibitors of mammalian DNA polymerases. Biochim Biophys Acta. 2002 Apr 29;1596(2):193-200. [2]. Dai W, et al. Euscaphic acid inhibits proliferation and promotes apoptosis of nasopharyngeal carcinoma cells by silencing the PI3K/AKT/mTOR signaling pathway. Am J Transl Res. 2019 Apr 15;11(4):2090-2098.

Density	1.2±0.1 g/cm3
Boiling Point	602.7±55.0 °C at 760 mmHg
Melting Point	262-264℃
Molecular Formula	C₃₀H₄₈O₅
Molecular Weight	488.699
Flash Point	332.3±28.0 °C
Exact Mass	488.350189
PSA	97.99000
LogP	6.21
Vapour Pressure	0.0±3.9 mmHg at 25°C
Index of Refraction	1.580

Hazard Codes	Xi

Precursor 0
DownStream 1
CAS#:13850-15-2 2α,3β,19-Trihyd...

Urs-12-en-28-oic acid, 2,3,19-trihydroxy-, (2α,3α)-

Jacarandic acid

(1R,2R,4aS,6aR,6aS,6bR,8aR,10S,11R,12aR,14bS)-1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid

2α,3α,19α-Trihydroxyurs-12-en-28-oic acid

(2α,3α)-2,3,19-Trihydroxyurs-12-en-28-oic acid

tormentic acid

Euscaphic acid

2,3,19-trihydroxyurs-12-en-28-oic acid

BioBioPha
China
Product Name: Euscaphic acid
Price: ￥1000.0/5mg
Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Euscaphic acid
Price: ￥3200.0/5mg
Purity: 98.0%
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DC Chemicals Limited
China
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: euscaphic acid
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Zhejiang Hangyu API Co., Ltd
China
Product Name: euscaphic acid
Price: ￥Inquiry/1kg
Purity: 99.5%
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Contact: Vinnie

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Euscaphic acid

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