3-Amino-7-(methylamino)phenothiazin-5-ium chloride

Modify Date: 2025-08-27 19:28:33

3-Amino-7-(methylamino)phenothiazin-5-ium chloride structure	Common Name	3-Amino-7-(methylamino)phenothiazin-5-ium chloride
	CAS Number	531-57-7	Molecular Weight	277.77
	Density	N/A	Boiling Point	385.1ºC at 760 mmHg
	Molecular Formula	C₁₃H₁₂ClN₃S	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	186.7ºC

Use of 3-Amino-7-(methylamino)phenothiazin-5-ium chloride

Azure C is the product of sequential enzymatic oxidation of Methylene blue (MB) or Azure B (AB). Azure C serves as the substrate of horseradish peroxidase (HRP)[1][2].

Name	azure C
Synonym	More Synonyms

Description	Azure C is the product of sequential enzymatic oxidation of Methylene blue (MB) or Azure B (AB). Azure C serves as the substrate of horseradish peroxidase (HRP)[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Ferreira-Leitão V S, et al. Methylene blue and azure B oxidation by horseradish peroxidase: a comparative evaluation of class II and class III peroxidases. Applied Catalysis B: Environmental, 2003, 42(2): 213-221. [2]. Lo Cascio F, et al. Azure C Targets and Modulates Toxic Tau Oligomers. ACS Chem Neurosci. 2018 Jun 20;9(6):1317-1326.

Description

Azure C is the product of sequential enzymatic oxidation of Methylene blue (MB) or Azure B (AB). Azure C serves as the substrate of horseradish peroxidase (HRP)[1][2].

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Ferreira-Leitão V S, et al. Methylene blue and azure B oxidation by horseradish peroxidase: a comparative evaluation of class II and class III peroxidases. Applied Catalysis B: Environmental, 2003, 42(2): 213-221.

[2]. Lo Cascio F, et al. Azure C Targets and Modulates Toxic Tau Oligomers. ACS Chem Neurosci. 2018 Jun 20;9(6):1317-1326.

Boiling Point	385.1ºC at 760 mmHg
Molecular Formula	C₁₃H₁₂ClN₃S
Molecular Weight	277.77
Flash Point	186.7ºC
Exact Mass	277.04400
PSA	79.18000
LogP	1.01270

MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SP5680000

CHEMICAL NAME :: Phenothiazin-5-ium, 3-amino-7-methylamino-, chloride

CAS REGISTRY NUMBER :: 531-57-7

LAST UPDATED :: 199504

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H12-N3-S.Cl

MOLECULAR WEIGHT :: 277.79

WISWESSER LINE NOTATION :: T C666 BN ISJ FZ MM1 &G &12/23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 20 umol/L/5H (Continuous)

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1536 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 36 (estimated) No. of Female Employees: 16 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	SP5680000
HS Code	2934300000

methylene blue

CAS#:152071-32-4

3-Amino-7-(meth...

CAS#:531-57-7

Literature: Materials Research Bulletin, , vol. 49, # 1 p. 544 - 551

HS Code	2934300000
Summary	2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.

Bioorg. Med. Chem. Lett. 19 , 4952-7, (2009)

Aggregated amyloid-beta (Abeta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular oligome...

Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct.

J. Biol. Chem. 282 , 10311-24, (2007)

Alzheimer disease is characterized by the abnormal aggregation of amyloid beta peptide into extracellular fibrillar deposits known as amyloid plaques. Soluble oligomers have been observed at early tim...

Note from the Biological Stain Commission: revision of azure B assay protocol.

Stain Technol. 63(1) , 65-9, (1988)

(7-aminophenothiazin-3-ylidene)-methylazanium,chloride

MFCD00067677

N-Methylthionine

EINECS 208-512-8

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 3-Amino-7-(methylamino)phenothiazin-5-ium chloride
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

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Price: ￥300/1 g

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3-Amino-7-(methylamino)phenothiazin-5-ium chloride

Use of 3-Amino-7-(methylamino)phenothiazin-5-ium chloride

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MSDS

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.