(±)-1,2-Propanediol-d6

Modify Date: 2024-04-03 17:37:07

(±)-1,2-Propanediol-d6 Structure
(±)-1,2-Propanediol-d6 structure
Common Name (±)-1,2-Propanediol-d6
CAS Number 52910-80-2 Molecular Weight 82.13140
Density 1.118 g/mL at 25ºC Boiling Point 187ºC(lit.)
Molecular Formula C3H2D6O2 Melting Point -60ºC(lit.)
MSDS USA Flash Point 103ºC

 Use of (±)-1,2-Propanediol-d6


(±)-1,2-Propanediol-d6 is the deuterium labeled (±)-1,2-Propanediol[1]. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many drug formulations to increase the solubility and stability of drugs[2].

 Names

Name 1,2-propane-d6-diol

 (±)-1,2-Propanediol-d6 Biological Activity

Description (±)-1,2-Propanediol-d6 is the deuterium labeled (±)-1,2-Propanediol[1]. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many drug formulations to increase the solubility and stability of drugs[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. De Cock RF, et al. Low but inducible contribution of renal elimination to clearance of propylene glycol in preterm and term neonates. Ther Drug Monit. 2014 Jun;36(3):278-87.  

 Chemical & Physical Properties

Density 1.118 g/mL at 25ºC
Boiling Point 187ºC(lit.)
Melting Point -60ºC(lit.)
Molecular Formula C3H2D6O2
Molecular Weight 82.13140
Flash Point 103ºC
Exact Mass 82.09010
PSA 40.46000
Storage condition 2-8°C